| Literature DB >> 16415041 |
Katherine E Burdick1, Todd Lencz, Birgit Funke, Christine T Finn, Philip R Szeszko, John M Kane, Raju Kucherlapati, Anil K Malhotra.
Abstract
Human intelligence is a trait that is known to be significantly influenced by genetic factors, and recent linkage data provide positional evidence to suggest that a region on chromosome 6p, previously associated with schizophrenia, may be linked to variation in intelligence. The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder characterized by cognitive dysfunction. We report an association between DTNBP1 genotype and general cognitive ability (g) in two independent cohorts, including 213 patients with schizophrenia or schizo-affective disorder and 126 healthy volunteers. These data suggest that DTNBP1 genetic variation influences human intelligence.Entities:
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Year: 2006 PMID： 16415041 DOI： 10.1093/hmg/ddi481
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150