Antibacterial cobalt(II) and zinc(II) complexes of pyrazine-derived NNO and NNN donor Schiff-bases.

A series of biologically active pyrazine-derived Schiff-base ligands have been synthesized by the condensation reaction of 2-aminopyrazine with salicylaldehyde and acetamidobenzylaldehyde. Then their cobalt(II), nickel(II) and zinc (II) complexes have been prepared. The biological evaluation of the simple uncomplexed ligand in comparison to their complexed compounds have been determined against bacterial strains e.g., Escherichia coil, Staphylococcus aureous and Pseudomonas aeruginosa.