| Literature DB >> 16414351 |
Michael B Ujiki1, Ben Milam, Xian-Zhong Ding, Alexandra B Roginsky, M Reza Salabat, Mark S Talamonti, Richard H Bell, Wenxin Gu, Richard B Silverman, Thomas E Adrian.
Abstract
Patients with pancreatic cancer have little hope for cure because no effective therapies are available. Sansalvamide A is a cyclic depsipeptide produced by a marine fungus. We investigated the effect of a novel sansalvamide A analogue on growth, cell-cycle phases, and induction of apoptosis in human pancreatic cancer cells in vitro. The sansalvamide analogue caused marked time- and concentration-dependent inhibition of DNA synthesis and cell proliferation of two human pancreatic cancer cell lines (AsPC-1 and S2-013). The analogue induced G0/G1 phase cell-cycle arrest and morphological changes suggesting induction of apoptosis. Apoptosis was confirmed by annexin V binding. This novel sansalvamide analogue inhibits growth of pancreatic cancer cells through G0/G1 arrest and induces apoptosis. Sansalvamide analogues may be valuable for the treatment of pancreatic cancer.Entities:
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Year: 2006 PMID： 16414351 DOI： 10.1016/j.bbrc.2005.12.131
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575