| Literature DB >> 16414251 |
E Bramon1, E Dempster, S Frangou, C McDonald, P Schoenberg, J H MacCabe, M Walshe, P Sham, D Collier, R M Murray.
Abstract
P300 wave anomalies correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The COMT gene is thought to influence cognitive performance and to be a susceptibility gene for schizophrenia. Unlike two previous studies, we found no significant influence of the COMT gene on P300 amplitude or latency in 189 individuals examined. The well-supported role of the COMT gene both in dopamine catabolism as well as in prefrontal cognition makes a strong theoretical case for the influence of COMT Val158Met polymorphism on P300 endophenotypes. However, the available neurophysiologic evidence suggests that any such association, if present, must be very subtle.Entities:
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Year: 2006 PMID： 16414251 DOI： 10.1016/j.eurpsy.2005.11.001
Source DB: PubMed Journal: Eur Psychiatry ISSN： 0924-9338 Impact factor: 5.361