Literature DB >> 16413960

Multifunctionality of human 17beta-hydroxysteroid dehydrogenases.

Gabriele Moeller1, Jerzy Adamski.   

Abstract

17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) belong to the family of short chain dehydrogenases/reductases (SDRs) and aldoketo-reductases (AKRs). Some of the enzymes were discovered and named due to their enzymatic activity on steroid substrates or according to their sequence homology to other 17beta-HSDs. During characterisation of these enzymes it turned out that their substrate specificity is broader than first expected and key functions of some 17beta-HSDs in vivo are probably not in steroid metabolism but in basic metabolic pathways. The issue of such multifunctionality is the topic of this review.

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Year:  2006        PMID： 16413960     DOI： 10.1016/j.mce.2005.11.031

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  31 in total

1.  Immunohistochemical analysis of 17β-hydroxysteroid dehydrogenase isozymes in human ovarian surface epithelium and epithelial ovarian carcinoma.

Authors:  Ken-ichi Motohara; Hironori Tashiro; Yumiko Taura; Takashi Ohba; Hidetaka Katabuchi
Journal:  Med Mol Morphol       Date:  2011-01-26       Impact factor: 2.309

2.  Estrogen-mediated regulation of mitochondrial gene expression.

Authors:  Maria I G Lopez Sanchez; Anne-Marie J Shearwood; Tiongsun Chia; Stefan M K Davies; Oliver Rackham; Aleksandra Filipovska
Journal:  Mol Endocrinol       Date:  2015-01

Review 3.  Regulation of 17β-hydroxysteroid dehydrogenases in cancer: regulating steroid receptor at pre-receptor stage.

Authors:  Mirja Rotinen; Joaquín Villar; Ignacio Encío
Journal:  J Physiol Biochem       Date:  2012-02-29       Impact factor: 4.158

4.  Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water.

Authors:  Alexandra Muñoz; Yana Chervona; Megan Hall; Thomas Kluz; Mary V Gamble; Max Costa
Journal:  Toxicol Appl Pharmacol       Date:  2015-03-07       Impact factor: 4.219

5.  Microarray analysis of hepatic gene expression in juvenile Japanese flounder Paralichthys olivaceus fed diets supplemented with fish or vegetable oils.

Authors:  Ubonrat Limtipsuntorn; Yutaka Haga; Hidehiro Kondo; Ikuo Hirono; Shuichi Satoh
Journal:  Mar Biotechnol (NY)       Date:  2013-09-20       Impact factor: 3.619

6.  Synthesis, purification and crystallographic studies of the C-terminal sterol carrier protein type 2 (SCP-2) domain of human hydroxysteroid dehydrogenase-like protein 2.

Authors:  Zhong Cheng; Yao Li; Chun Sui; Xiaobo Sun; Yong Xie
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-06-27       Impact factor: 1.056

7.  The stimulation of HSD17B7 expression by estradiol provides a powerful feed-forward mechanism for estradiol biosynthesis in breast cancer cells.

Authors:  Aurora Shehu; Constance Albarracin; Y Sangeeta Devi; Kristin Luther; Julia Halperin; Jamie Le; Jifang Mao; Rachel W Duan; Jonna Frasor; Geula Gibori
Journal:  Mol Endocrinol       Date:  2011-03-03

Review 8.  Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery.

Authors:  Gonda Konings; Linda Brentjens; Bert Delvoux; Tero Linnanen; Karlijn Cornel; Pasi Koskimies; Marlies Bongers; Roy Kruitwagen; Sofia Xanthoulea; Andrea Romano
Journal:  Front Pharmacol       Date:  2018-09-19       Impact factor: 5.810

9.  Independent confirmation of association between metabolic phenotypes of polycystic ovary syndrome and variation in the type 6 17beta-hydroxysteroid dehydrogenase gene.

Authors:  Michelle R Jones; Ruchi Mathur; Jinrui Cui; Xiuqing Guo; Ricardo Azziz; Mark O Goodarzi
Journal:  J Clin Endocrinol Metab       Date:  2009-10-16       Impact factor: 5.958

10.  Genomic and neural analysis of the estradiol-synthetic pathway in the zebra finch.

Authors:  Sarah E London; David F Clayton
Journal:  BMC Neurosci       Date:  2010-04-01       Impact factor: 3.288
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