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Literature DB >> 16413542

Extracellular adenine nucleotides inhibit the release of major monocyte recruiters by human monocyte-derived dendritic cells.

Michael Horckmans¹, Brice Marcet, Frédéric Marteau, Frédéric Bulté, Arielle Maho, Marc Parmentier, Jean-Marie Boeynaems, Didier Communi.

Abstract

Extracellular ATP is known to affect the maturation of monocyte-derived dendritic cells mainly by regulation of cytokines and costimulatory molecules. The present study describes the inhibition of MCP-1 (CCL2) and MIP-1alpha (CCL3) release by human monocyte-derived dendritic cells in response to adenine nucleotides. Our pharmacological data support the involvement of P2Y11 and P2Y1 purinergic receptors in the downregulation of these major monocyte recruiters. Migration assays have demonstrated that supernatants of dendritic cells treated with adenine nucleotides or anti-MCP-1/MIP-1alpha blocking antibodies display a strongly reduced capacity to attract monocytes and immature dendritic cells.

Entities: Chemical Gene Species

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Year: 2006 PMID： 16413542 DOI： 10.1016/j.febslet.2005.12.091

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

6 in total

1. Regulation of innate immunity by extracellular nucleotides.

Authors: Stefania Gorini; Lucia Gatta; Laura Pontecorvo; Laura Vitiello; Andrea la Sala
Journal: Am J Blood Res Date: 2013-01-17

Review 2. A critical look at the function of the P2Y11 receptor.

Authors: Karin Dreisig; Birgitte Rahbek Kornum
Journal: Purinergic Signal Date: 2016-05-31 Impact factor: 3.765

3. Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.

Authors: Yohei Mineharu; A K M Ghulam Muhammad; Kader Yagiz; Marianela Candolfi; Kurt M Kroeger; Weidong Xiong; Mariana Puntel; Chunyan Liu; Eva Levy; Claudia Lugo; Adrina Kocharian; James P Allison; Michael A Curran; Pedro R Lowenstein; Maria G Castro
Journal: Neurotherapeutics Date: 2012-10 Impact factor: 7.620

Extracellular adenine nucleotides inhibit the release of major monocyte recruiters by human monocyte-derived dendritic cells.

1. Regulation of innate immunity by extracellular nucleotides.

Review 2. A critical look at the function of the P2Y11 receptor.

3. Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.

Review 4. The role of pannexin1 in the induction and resolution of inflammation.

Review 5. Purinergic signalling and immune cells.

6. P2Y1R Ligation Suppresses Th17 Cell Differentiation and Alleviates Colonic Inflammation in an AMPK-Dependent Manner.