OBJECTIVES: To investigate c-jun oncoprotein (JUN) expression in diseases of the human prostate gland at the tissue level and to determine its relationship to clinicopathologic variables. METHODS: The expression of JUN was studied using immunohistochemistry in archival tissue from benign prostatic hyperplasia (BPH) (n = 16) and prostate adenocarcinoma (PCa) (n = 36) specimens. RESULTS: JUN-specific positive nuclear immunostaining was observed in 13 (81.25%) of 16 BPH and 31 (86.1%) of 36 PCa specimens. JUN-specific immunostaining was significantly stronger in the PCa than in the BPH tissue (P = 0.006). In the PCa tissue, no significant correlation was found between JUN immunohistochemical expression and tumor histologic grade (Gleason score) or serum prostate-specific antigen level. CONCLUSIONS: JUN expression may play a role in normal cell function of the prostatic epithelium and is expressed in most BPH and PCa samples. The finding that JUN-specific immunostaining intensity was stronger in the vast majority of PCa than in the BPH samples implies that the role of c-jun may be enhanced during malignant transformation.
OBJECTIVES: To investigate c-jun oncoprotein (JUN) expression in diseases of the human prostate gland at the tissue level and to determine its relationship to clinicopathologic variables. METHODS: The expression of JUN was studied using immunohistochemistry in archival tissue from benign prostatic hyperplasia (BPH) (n = 16) and prostate adenocarcinoma (PCa) (n = 36) specimens. RESULTS: JUN-specific positive nuclear immunostaining was observed in 13 (81.25%) of 16 BPH and 31 (86.1%) of 36 PCa specimens. JUN-specific immunostaining was significantly stronger in the PCa than in the BPH tissue (P = 0.006). In the PCa tissue, no significant correlation was found between JUN immunohistochemical expression and tumor histologic grade (Gleason score) or serum prostate-specific antigen level. CONCLUSIONS: JUN expression may play a role in normal cell function of the prostatic epithelium and is expressed in most BPH and PCa samples. The finding that JUN-specific immunostaining intensity was stronger in the vast majority of PCa than in the BPH samples implies that the role of c-jun may be enhanced during malignant transformation.
Authors: Craig S Charron; Harry D Dawson; George P Albaugh; Patrick M Solverson; Bryan T Vinyard; Gloria I Solano-Aguilar; Aleksey Molokin; Janet A Novotny Journal: J Nutr Date: 2015-09-30 Impact factor: 4.798
Authors: Aurelien Descazeaud; Mark A Rubin; Matthias Hofer; Sunita Setlur; Nathalie Nikolaief; Francis Vacherot; Pascale Soyeux; Laurence Kheuang; Claude C Abbou; Yves Allory; Alexandre de la Taille Journal: Diagn Mol Pathol Date: 2008-12
Authors: Eric C Bolton; Alex Y So; Christina Chaivorapol; Christopher M Haqq; Hao Li; Keith R Yamamoto Journal: Genes Dev Date: 2007-08-15 Impact factor: 11.361