OBJECTIVE: Cocaine-induced paranoia (CIP), an irrational intense suspicion of others, is a common manifestation of cocaine dependence. Both environmental and genetic factors are thought to play a role, but the specific nature of such contributions is poorly understood. METHODS: Demographic, diagnostic, and cocaine-use data were obtained from 420 cocaine-dependent, genetically confirmed, full-sibling pairs (N=840 subjects) interviewed with the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Probands with and without CIP were compared; then, factors associated with sibling CIP status were analyzed by logistic regression. Alcohol dependence, a known heritable phenotype, was analyzed as a positive control. RESULTS: Of 420 probands, 273 (65%) experienced CIP. Probands with CIP were more severely dependent upon cocaine, had an earlier age of onset, were more likely to smoke cocaine, and used cocaine less frequently during the preceding year. Independent analyses of siblings replicated two of the former (i.e., dependence severity and age of onset). Probands with CIP also had a non-significantly higher proportion of siblings with the trait (66% versus 59%). Probands with concurrent alcohol dependence were confirmed to have significantly higher rates of alcoholism among their siblings. CONCLUSIONS: Severity of cocaine dependence and age of onset appear to be important risk factors for CIP. Concordance for CIP between siblings did not emerge as significant in our analyses.
OBJECTIVE:Cocaine-induced paranoia (CIP), an irrational intense suspicion of others, is a common manifestation of cocaine dependence. Both environmental and genetic factors are thought to play a role, but the specific nature of such contributions is poorly understood. METHODS: Demographic, diagnostic, and cocaine-use data were obtained from 420 cocaine-dependent, genetically confirmed, full-sibling pairs (N=840 subjects) interviewed with the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA). Probands with and without CIP were compared; then, factors associated with sibling CIP status were analyzed by logistic regression. Alcohol dependence, a known heritable phenotype, was analyzed as a positive control. RESULTS: Of 420 probands, 273 (65%) experienced CIP. Probands with CIP were more severely dependent upon cocaine, had an earlier age of onset, were more likely to smoke cocaine, and used cocaine less frequently during the preceding year. Independent analyses of siblings replicated two of the former (i.e., dependence severity and age of onset). Probands with CIP also had a non-significantly higher proportion of siblings with the trait (66% versus 59%). Probands with concurrent alcohol dependence were confirmed to have significantly higher rates of alcoholism among their siblings. CONCLUSIONS: Severity of cocaine dependence and age of onset appear to be important risk factors for CIP. Concordance for CIP between siblings did not emerge as significant in our analyses.
Authors: Peter D Alexander; Kristina M Gicas; Taylor S Willi; Clara N Kim; Veronika Boyeva; Ric M Procyshyn; Geoff N Smith; Allen E Thornton; William J Panenka; Andrea A Jones; Fidel Vila-Rodriguez; Donna J Lang; G William MacEwan; William G Honer; Alasdair M Barr Journal: Psychopharmacology (Berl) Date: 2017-02-11 Impact factor: 4.530
Authors: Rasmon Kalayasiri; Joel Gelernter; Lindsay Farrer; Roger Weiss; Kathleen Brady; Ralitza Gueorguieva; Henry R Kranzler; Robert T Malison Journal: Drug Alcohol Depend Date: 2009-11-26 Impact factor: 4.492
Authors: Rungnapa Ittiwut; Jennifer B Listman; Chupong Ittiwut; Joseph F Cubells; Roger D Weiss; Kathleen Brady; David Oslin; Lindsay A Farrer; Henry R Kranzler; Joel Gelernter Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2011-06-08 Impact factor: 3.568
Authors: Teerayuth Rungnirundorn; Viroj Verachai; Joel Gelernter; Robert T Malison; Rasmon Kalayasiri Journal: J Addict Med Date: 2017 Jan/Feb Impact factor: 3.702
Authors: Robert T Malison; Rasmon Kalayasiri; Kittipong Sanichwankul; Atapol Sughondhabirom; Apiwat Mutirangura; Brian Pittman; Ralitza Gueorguieva; Henry R Kranzler; Joel Gelernter Journal: Addict Behav Date: 2011 Jan-Feb Impact factor: 3.913
Authors: Rasmon Kalayasiri; Viroj Verachai; Joel Gelernter; Apiwat Mutirangura; Robert T Malison Journal: Addiction Date: 2014-03-17 Impact factor: 6.526