| Literature DB >> 16412563 |
Jean-Paul Duong Van Huyen1, Sandrine Delignat, Jagadeesh Bayry, Michel D Kazatchkine, Patrick Bruneval, Antonino Nicoletti, Srini V Kaveri.
Abstract
Viscum album (VA) preparations consist of aqueous extracts of different types of lectins of mistletoe. VA exert cytotoxic and immunomodulatory properties that may be relevant for the inhibition of tumor growth. We addressed the effects of VA preparation VA Qu FrF on growth of B16F1 melanoma implanted in mice and on proliferation and cytokine synthesis of splenocytes. In C57BL6 mice, inhibition of tumor growth by VA was associated with an enhancement of splenocyte proliferation and with an up-regulation of IL-12 secretion. In IL-12-deficient strain of mice the inhibition of melanoma growth by VA and the splenocyte proliferation were abrogated. Results from the present study strongly suggest a crucial role of IL-12 in the anti-tumor properties of VA extracts.Entities:
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Year: 2006 PMID： 16412563 DOI： 10.1016/j.canlet.2005.11.016
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679