Literature DB >> 16411680

Copper complexes of thiosemicarbazone-pyridylhydrazine (THYNIC) hybrid ligands: a new versatile potential bifunctional chelator for copper radiopharmaceuticals.

Andrew R Cowley1, Jonathan R Dilworth, Paul S Donnelly, Jonathan M White.   

Abstract

Two new thiosemicarbazone-pyridylhydrazine (THYNIC) hybrid ligands have been synthesized. Copper(II) and copper(I) complexes of the ligands have been prepared and characterized by X-ray crystallography. Cyclic voltammetry measurements show that the copper(II) complexes undergo quasi-reversible reductions at biologically accessible potentials. One of the ligands, bearing a pendant carboxylate arm, has been conjugated to N-alpha-(tert-butoxycarbonyl)-L-lysine.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16411680     DOI： 10.1021/ic0514492

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  5 in total

Review 1.  Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease.

Authors:  Thaddeus J Wadas; Edward H Wong; Gary R Weisman; Carolyn J Anderson
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

Review 2.  The development of copper radiopharmaceuticals for imaging and therapy.

Authors:  Monica Shokeen; Thaddeus J Wadas
Journal:  Med Chem       Date:  2011-09       Impact factor: 2.745

3.  Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest.

Authors:  Dharmasivam Mahendiran; Sethu Amuthakala; Nattamai S P Bhuvanesh; Raju Senthil Kumar; Aziz Kalilur Rahiman
Journal:  RSC Adv       Date:  2018-05-09       Impact factor: 4.036

Review 4.  Radiopharmaceuticals in preclinical and clinical development for monitoring of therapy with PET.

Authors:  Mark P S Dunphy; Jason S Lewis
Journal:  J Nucl Med       Date:  2009-04-20       Impact factor: 10.057

5.  Synthesis, Characterization and Biological Activity of Novel Cu(II) Complexes of 6-Methyl-2-Oxo-1,2-Dihydroquinoline-3-Carbaldehyde-4n-Substituted Thiosemicarbazones.

Authors:  Eswaran Ramachandran; Valentina Gandin; Roberta Bertani; Paolo Sgarbossa; Karuppannan Natarajan; Nattamai S P Bhuvanesh; Alfonso Venzo; Alfonso Zoleo; Mirto Mozzon; Alessandro Dolmella; Alberto Albinati; Carlo Castellano; Nuno Reis Conceição; M Fátima C Guedes da Silva; Cristina Marzano
Journal:  Molecules       Date:  2020-04-17       Impact factor: 4.411
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.