S Sivaprasad1, N V Chong. 1. Laser and Retinal Research Unit, King's College Hospital, Denmark Hill, London, UK.
Abstract
PURPOSE: Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. There are increasing evidences to suggest the complement system may play a significant role on the pathogenesis of AMD. In this review, we summarise the current research in this area. METHODS: Review of literature. RESULTS: The complement system is a complex system with several activation pathways. Complement factor H (CFH) polymorphisms has been associated with increase risk of AMD. CFH is an inhibitor protein; the polymorphisms might cause uncontrolled activation by initiation events. CONCLUSION: Further studies on the molecular basis of the complement-mediated pathogenesis of AMD may offer novel therapy to AMD.
PURPOSE: Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. There are increasing evidences to suggest the complement system may play a significant role on the pathogenesis of AMD. In this review, we summarise the current research in this area. METHODS: Review of literature. RESULTS: The complement system is a complex system with several activation pathways. Complement factor H (CFH) polymorphisms has been associated with increase risk of AMD. CFH is an inhibitor protein; the polymorphisms might cause uncontrolled activation by initiation events. CONCLUSION: Further studies on the molecular basis of the complement-mediated pathogenesis of AMD may offer novel therapy to AMD.
Authors: Jessica M Skeie; John H Fingert; Stephen R Russell; Edwin M Stone; Robert F Mullins Journal: Invest Ophthalmol Vis Sci Date: 2010-05-19 Impact factor: 4.799
Authors: Gregory S Hageman; Lisa S Hancox; Andrew J Taiber; Karen M Gehrs; Don H Anderson; Lincoln V Johnson; Monte J Radeke; David Kavanagh; Anna Richards; John Atkinson; Seppo Meri; Julie Bergeron; Jana Zernant; Joanna Merriam; Bert Gold; Rando Allikmets; Michael Dean Journal: Ann Med Date: 2006 Impact factor: 4.709