BACKGROUND: Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression. OBJECTIVES: We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age > or = 65 years) from the Cardiovascular Health Study. METHODS: Selected participants were free of clinical CVD at baseline. Non-exclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n = 842; CVD death = 310). A total 643 subjects were free of events during follow-up. RESULTS: sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL(-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events. CONCLUSIONS: While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.
BACKGROUND:Intracellular adhesion molecule-1 (ICAM-1) regulates leukocyte-endothelial attachment, a process crucial to atherosclerosis. Circulating soluble ICAM-1 (sICAM-1) may serve as a marker of cardiovascular disease (CVD) progression. OBJECTIVES: We examined the association of sICAM-1 with measures of subclinical CVD and risk of incident CVD events and death in older men and women (age > or = 65 years) from the Cardiovascular Health Study. METHODS: Selected participants were free of clinical CVD at baseline. Non-exclusive incident case groups were angina (n = 534), myocardial infarction (n = 304), stroke (n = 327), and death (n = 842; CVD death = 310). A total 643 subjects were free of events during follow-up. RESULTS: sICAM-1 was positively associated with C-reactive protein, interleukin-6 and fibrinogen and measures of subclinical CVD in these older men and women. In Cox regression models adjusted for age, gender, and race, increasing levels of sICAM-1 were associated with increased risk of all cause mortality in men and women. Hazard ratios (95% confidence intervals) for a one standard deviation increase in sICAM-1 (89.7 ng mL(-1)) were 1.3 (1.1-1.4) in men and 1.2 (1.1-1.3) in women. sICAM-1 was associated with increased risk of CVD death in women (1.2; 1.0-1.5), but not men (1.1; 0.9-1.3). There were no associations of sICAM-1 with non-fatal CVD events. CONCLUSIONS: While sICAM-1 was associated with death in older men and women, there was a more marked association between sICAM-1 and CVD death in women.
Authors: Jason Baker; Woubeshet Ayenew; Harrison Quick; Katherine Huppler Hullsiek; Russell Tracy; Keith Henry; Daniel Duprez; James D Neaton Journal: J Infect Dis Date: 2010-01-15 Impact factor: 5.226
Authors: Robert C Kaplan; Aileen P McGinn; Alison E Baird; Susan L Hendrix; Charles Kooperberg; John Lynch; Daniel M Rosenbaum; Karen C Johnson; Howard D Strickler; Sylvia Wassertheil-Smoller Journal: J Stroke Cerebrovasc Dis Date: 2008 Nov-Dec Impact factor: 2.136
Authors: Amal A Mohamed; Laila Rashed; Hoda Amin; Manal Abu-Farha; Soheir Abu El Fadl; Sameh Pakhoum Journal: Ann Saudi Med Date: 2010 Nov-Dec Impact factor: 1.526
Authors: Christopher Keller; Ronit Katz; Mark J Sarnak; Linda F Fried; Bryan Kestenbaum; Mary Cushman; Michael G Shlipak Journal: Nephrol Dial Transplant Date: 2009-09-03 Impact factor: 5.992
Authors: Renate B Schnabel; Xiaoyan Yin; Martin G Larson; Jennifer F Yamamoto; João D Fontes; Sekar Kathiresan; Jian Rong; Daniel Levy; John F Keaney; Thomas J Wang; Joanne M Murabito; Ramachandran S Vasan; Emelia J Benjamin Journal: Arterioscler Thromb Vasc Biol Date: 2013-05-02 Impact factor: 8.311
Authors: Junenette L Peters; Laura D Kubzansky; Ai Ikeda; Shona C Fang; David Sparrow; Marc G Weisskopf; Robert O Wright; Pantel Vokonas; Howard Hu; Joel Schwartz Journal: Environ Health Perspect Date: 2011-12-05 Impact factor: 9.031
Authors: Cheryl R Clark; Paul M Ridker; Mark J Ommerborn; Carrie E Huisingh; Brent Coull; Julie E Buring; Lisa F Berkman Journal: BMC Public Health Date: 2012-03-20 Impact factor: 3.295
Authors: C L Falconer; A R Cooper; J P Walhin; D Thompson; A S Page; T J Peters; A A Montgomery; D J Sharp; C M Dayan; R C Andrews Journal: Nutr Metab Cardiovasc Dis Date: 2014-04-26 Impact factor: 4.222