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Literature DB >> 16409158

Current concepts in thrombotic thrombocytopenic purpura.

Abstract

Recent advances have demonstrated that thrombotic thrombocytopenic purpura (TTP), characterized by widespread thrombosis in the arterioles and capillaries, is caused by deficiency of a circulating zinc metalloprotease, ADAMTS13. Two types of TTP are recognized: autoimmune TTP, caused by inhibitory antibodies of ADAMTS13, and hereditary TTP, caused by genetic mutations of ADAMTS13. This article reviews the characteristics and function of ADAMTS13, the mechanism by which ADAMTS13 deficiency may lead to thrombosis, and the causes of ADAMTS13 deficiency. It also discusses how the new knowledge may improve the diagnosis and treatment of this previously mysterious disorder.

Entities: Disease Gene

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Year: 2006 PMID： 16409158 PMCID： PMC2426955 DOI： 10.1146/annurev.med.57.061804.084505

Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739

70 in total

1. Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord blood.

Authors: Han-Mou Tsai; Ravindra Sarode; Katharine A Downes
Journal: Thromb Res Date: 2002-11-01 Impact factor: 3.944

2. Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpura.

Authors: Han-Mou Tsai; Keith Shulman
Journal: Eur J Haematol Date: 2003-03 Impact factor: 2.997

3. Cleavage of the ADAMTS13 propeptide is not required for protease activity.

Authors: Elaine M Majerus; Xinglong Zheng; Elodee A Tuley; J Evan Sadler
Journal: J Biol Chem Date: 2003-09-15 Impact factor: 5.157

4. Transplantation-associated thrombotic microangiopathy is associated with transplantation from unrelated donors, acute graft-versus-host disease and venoocclusive disease of the liver.

Authors: Andrew S Daly; Wanda S Hasegawa; Jeffrey H Lipton; Hans A Messner; Thomas L Kiss
Journal: Transfus Apher Sci Date: 2002-08 Impact factor: 1.764

5. ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage.

Authors: Kenji Soejima; Masanori Matsumoto; Koichi Kokame; Hideo Yagi; Hiromichi Ishizashi; Hiroaki Maeda; Chikateru Nozaki; Toshiyuki Miyata; Yoshihiro Fujimura; Tomohiro Nakagaki
Journal: Blood Date: 2003-07-17 Impact factor: 22.113

6. Nonneutralizing IgM and IgG antibodies to von Willebrand factor-cleaving protease (ADAMTS-13) in a patient with thrombotic thrombocytopenic purpura.

Authors: Friedrich Scheiflinger; Paul Knöbl; Bettina Trattner; Barbara Plaimauer; Gabriele Mohr; Michael Dockal; Friedrich Dorner; Manfred Rieger
Journal: Blood Date: 2003-07-10 Impact factor: 22.113

Review 7. Genetic defects leading to hereditary thrombotic thrombocytopenic purpura.

Authors: Koichi Kokame; Toshiyuki Miyata
Journal: Semin Hematol Date: 2004-01 Impact factor: 3.851

8. Von Willebrand factor-cleaving protease (ADAMTS13) in thrombocytopenic disorders: a severely deficient activity is specific for thrombotic thrombocytopenic purpura.

Authors: Valentina Bianchi; Rodolfo Robles; Lorenzo Alberio; Miha Furlan; Bernhard Lämmle
Journal: Blood Date: 2002-07-15 Impact factor: 22.113

9. Thrombotic thrombocytopenic purpura in a newborn.

Authors: Paul T Jubinsky; Richard Moraille; Han-Mou Tsai
Journal: J Perinatol Date: 2003-01 Impact factor: 2.521

10. Changes in von Willebrand factor-cleaving protease (ADAMTS13) activity after infusion of desmopressin.

Authors: Rosemarie A Reiter; Paul Knöbl; Katalin Varadi; Peter L Turecek
Journal: Blood Date: 2002-09-19 Impact factor: 22.113

24 in total

Review 1. ADAMTS13 and microvascular thrombosis.

Authors: Han-Mou Tsai
Journal: Expert Rev Cardiovasc Ther Date: 2006-11

Review 2. Advantages and limits of ADAMTS13 testing in thrombotic thrombocytopenic purpura.

Authors: Massimo Franchini; Pier Mannuccio Mannucci
Journal: Blood Transfus Date: 2008-07 Impact factor: 3.443

3. Measurement of ADAMTS13.

Authors: Han-Mou Tsai
Journal: Int Rev Thromb Date: 2006

4. Shear stress-induced unfolding of VWF accelerates oxidation of key methionine residues in the A1A2A3 region.

Authors: Xiaoyun Fu; Junmei Chen; Ryan Gallagher; Ying Zheng; Dominic W Chung; José A López
Journal: Blood Date: 2011-09-13 Impact factor: 22.113

5. Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat).

Authors: Klilah Hershko; Vijaya L Simhadri; Adam Blaisdell; Ryan C Hunt; Jordan Newell; Sandra C Tseng; Alon Y Hershko; Jae Won Choi; Zuben E Sauna; Andrew Wu; Richard J Bram; Anton A Komar; Chava Kimchi-Sarfaty
Journal: J Biol Chem Date: 2012-11-09 Impact factor: 5.157