Literature DB >> 16408891

New latent fluorophore for DT diaphorase.

Sheng-Tung Huang1, Yuh-Ling Lin.   

Abstract

[reaction: see text] This study describes the design and synthesis of a novel latent fluorophore 3 for DT diaphorase based on the trimethyl lock effect and characterization of its enzymatic kinetics. Fluorophore 3 is also a sensitive fluorimetric reagent for detecting glucose when coupled with DTD and glucose dehydrogenase.

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Year:  2006        PMID: 16408891     DOI: 10.1021/ol052635e

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  6 in total

1.  A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells.

Authors:  Melissa M Yatzeck; Luke D Lavis; Tzu-Yuan Chao; Sunil S Chandran; Ronald T Raines
Journal:  Bioorg Med Chem Lett       Date:  2008-06-10       Impact factor: 2.823

2.  Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells.

Authors:  Rex W Watkins; Luke D Lavis; Vanessa M Kung; Georgyi V Los; Ronald T Raines
Journal:  Org Biomol Chem       Date:  2009-07-31       Impact factor: 3.876

3.  Human NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groups.

Authors:  Maria F Mendoza; Nicole M Hollabaugh; Suraj U Hettiarachchi; Robin L McCarley
Journal:  Biochemistry       Date:  2012-09-28       Impact factor: 3.162

4.  Activatable Optical Probes for the Detection of Enzymes.

Authors:  Christopher R Drake; David C Miller; Ella F Jones
Journal:  Curr Org Synth       Date:  2011-08       Impact factor: 1.975

5.  Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology.

Authors:  Michael N Levine; Ronald T Raines
Journal:  Chem Sci       Date:  2012-05-30       Impact factor: 9.825

6.  Profluorogenic reductase substrate for rapid, selective, and sensitive visualization and detection of human cancer cells that overexpress NQO1.

Authors:  William C Silvers; Bijeta Prasai; David H Burk; Matthew L Brown; Robin L McCarley
Journal:  J Am Chem Soc       Date:  2012-12-27       Impact factor: 15.419

  6 in total

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