| Literature DB >> 16408791 |
Alexandra Testard1, Laurent Picot, Olivier Lozach, Melina Blairvacq, Laurent Meijer, Laurence Murillo, Jean-Marie Piot, Valérie Thiéry, Thierry Besson.
Abstract
The microwave-assisted synthesis of a family of 2,8-substituted thiazoloquinazolinones is described. The preliminary evaluation of the antiproliferative activity and the capacity of these molecules to inhibit CDKs and GSK-3 are reported. A lead compound was identified, constituting a scaffold from which more potent inhibitors could be designed.Entities:
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Year: 2005 PMID： 16408791 DOI： 10.1080/14756360500212399
Source DB: PubMed Journal: J Enzyme Inhib Med Chem ISSN： 1475-6366 Impact factor: 5.051