Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Literature DB >> 16408088

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Abstract

Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2005 PMID： 16408088 DOI： 10.1038/nchembio753

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

Keyword Cloud
Cited

160 in total

1. Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish.

Authors: Robert N Wilkinson; Marco J Koudijs; Roger K Patient; Philip W Ingham; Stefan Schulte-Merker; Fredericus J M van Eeden
Journal: Blood Date: 2012-06-05 Impact factor: 22.113

10. Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.

Authors: Weiguang Wang; Na Lian; Lingzhen Li; Heather E Moss; Weixi Wang; Daniel S Perrien; Florent Elefteriou; Xiangli Yang
Journal: Development Date: 2009-11-11 Impact factor: 6.868

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

1. Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish.

Review 2. Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms.

3. Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells.

4. Transgenic enrichment of mouse embryonic stem cell-derived progenitor motor neurons.

5. Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.

6. A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription.

7. Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons.

8. Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma.

9. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium.

10. Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription.