| Literature DB >> 16407493 |
P W Christopherson1, T A Insalaco, V L van Santen, L Livesey, C Bourne, M K Boudreaux.
Abstract
Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin alpha(IIb)beta3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.Entities:
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Year: 2006 PMID： 16407493 DOI： 10.1354/vp.43-1-78
Source DB: PubMed Journal: Vet Pathol ISSN： 0300-9858 Impact factor: 2.221