Literature DB >> 16406782

Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.

Darrell E Hurt1, Amanda E Sutton, Jon Clardy.   

Abstract

Therapeutic agents brequinar sodium and leflunomide (Arava) work by binding in a hydrophobic tunnel formed by a highly variable N-terminus of family 2 dihydroorotate dehydrogenase (DHODH). The X-ray crystallographic structure of an analog of brequinar bound to human DHODH was determined. In silico screening of a library of compounds suggested another subset of brequinar analogs that do not inhibit human DHODH as potentially effective inhibitors of Plasmodium falciparum DHODH.

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Year:  2006        PMID： 16406782     DOI： 10.1016/j.bmcl.2005.12.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.

Authors:  Evan R Abt; Ethan W Rosser; Matthew A Durst; Vincent Lok; Soumya Poddar; Thuc M Le; Arthur Cho; Woosuk Kim; Liu Wei; Janet Song; Joseph R Capri; Shili Xu; Nanping Wu; Roger Slavik; Michael E Jung; Robert Damoiseaux; Johannes Czernin; Timothy R Donahue; Arnon Lavie; Caius G Radu
Journal:  Cell Chem Biol       Date:  2019-11-13       Impact factor: 8.116

2.  Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.

Authors:  Michael L Booker; Cecilia M Bastos; Martin L Kramer; Robert H Barker; Renato Skerlj; Amar Bir Sidhu; Xiaoyi Deng; Cassandra Celatka; Joseph F Cortese; Jose E Guerrero Bravo; Keila N Crespo Llado; Adelfa E Serrano; Iñigo Angulo-Barturen; María Belén Jiménez-Díaz; Sara Viera; Helen Garuti; Sergio Wittlin; Petros Papastogiannidis; Jing-Wen Lin; Chris J Janse; Shahid M Khan; Manoj Duraisingh; Bradley Coleman; Elizabeth J Goldsmith; Margaret A Phillips; Benito Munoz; Dyann F Wirth; Jeffrey D Klinger; Roger Wiegand; Edmund Sybertz
Journal:  J Biol Chem       Date:  2010-08-11       Impact factor: 5.157

3.  Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Authors:  Vishal Patel; Michael Booker; Martin Kramer; Leila Ross; Cassandra A Celatka; Leah M Kennedy; Jeffrey D Dvorin; Manoj T Duraisingh; Piotr Sliz; Dyann F Wirth; Jon Clardy
Journal:  J Biol Chem       Date:  2008-10-08       Impact factor: 5.157

4.  Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.

Authors:  James Reigle; Dina Secic; Jacek Biesiada; Collin Wetzel; Behrouz Shamsaei; Johnson Chu; Yuanwei Zang; Xiang Zhang; Nicholas J Talbot; Megan E Bischoff; Yongzhen Zhang; Charuhas V Thakar; Krishnanath Gaitonde; Abhinav Sidana; Hai Bui; John T Cunningham; Qing Zhang; Laura S Schmidt; W Marston Linehan; Mario Medvedovic; David R Plas; Julio A Landero Figueroa; Jarek Meller; Maria F Czyzyk-Krzeska
Journal:  J Clin Invest       Date:  2021-01-04       Impact factor: 14.808

5.  Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii.

Authors:  Miryam Andrea Hortua Triana; My-Hang Huynh; Manuel F Garavito; Barbara A Fox; David J Bzik; Vern B Carruthers; Monika Löffler; Barbara H Zimmermann
Journal:  Mol Biochem Parasitol       Date:  2012-05-08       Impact factor: 1.759

Review 6.  DHODH and cancer: promising prospects to be explored.

Authors:  Yue Zhou; Lei Tao; Xia Zhou; Zeping Zuo; Jin Gong; Xiaocong Liu; Yang Zhou; Chunqi Liu; Na Sang; Huan Liu; Jiao Zou; Kun Gou; Xiaowei Yang; Yinglan Zhao
Journal:  Cancer Metab       Date:  2021-05-10

7.  Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.

Authors:  Liang Zhang; Priyabrata Das; Mirco Schmolke; Balaji Manicassamy; Yaming Wang; Xiaoyi Deng; Ling Cai; Benjamin P Tu; Christian V Forst; Michael G Roth; David E Levy; Adolfo García-Sastre; Jef de Brabander; Margaret A Phillips; Beatriz M A Fontoura
Journal:  J Cell Biol       Date:  2012-02-06       Impact factor: 10.539

8.  Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors.

Authors:  Kuei-Chung Shih; Chi-Ching Lee; Chi-Neu Tsai; Yu-Shan Lin; Chuan-Yi Tang
Journal:  PLoS One       Date:  2014-02-04       Impact factor: 3.240

9.  The Establishment of an Antiviral State by Pyrimidine Synthesis Inhibitor is Cell Type-Specific.

Authors:  Donghoon Chung
Journal:  J Antimicrob Agents       Date:  2015-11-06

10.  Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.

Authors:  John White; Satish K Dhingra; Xiaoyi Deng; Farah El Mazouni; Marcus C S Lee; Gustavo A Afanador; Aloysus Lawong; Diana R Tomchick; Caroline L Ng; Jade Bath; Pradipsinh K Rathod; David A Fidock; Margaret A Phillips
Journal:  ACS Infect Dis       Date:  2018-11-13       Impact factor: 5.084
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