| Literature DB >> 16406629 |
Victoria E Wagner1, John G Frelinger, Richard K Barth, Barbara H Iglewski.
Abstract
A recent study suggests that the opportunistic pathogen Pseudomonas aeruginosa can actively monitor the host immune system. The P. aeruginosa outer membrane protein OprF was found to bind specifically to the cytokine interferon-gamma (IFN-gamma), and this interaction upregulated production of virulence factors through a cell-cell communication system known as quorum sensing (QS). Taken together with previous findings that P. aeruginosa QS can alter the host immune response (e.g. by activation of IFN-gamma), these data illustrate an exciting new element of bacteria-host interactions in which the P. aeruginosa quorum-sensing system both senses and modulates the host immune state.Entities:
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Year: 2006 PMID： 16406629 DOI： 10.1016/j.tim.2005.12.002
Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079