| Literature DB >> 16406613 |
Wesley P Blackaby1, John R Atack, Frances Bromidge, José L Castro, Simon C Goodacre, David J Hallett, Richard T Lewis, George R Marshall, Andrew Pike, Alison J Smith, Leslie J Street, David F D Tattersall, Keith A Wafford.
Abstract
Imidazo[1,2-a]pyrimidines are GABA(A) receptor benzodiazepine binding site ligands which can exhibit functional selectivity for the alpha(3) subtype over the alpha(1) subtype. SAR studies to optimize this functional selectivity are described.Entities:
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Year: 2006 PMID： 16406613 DOI： 10.1016/j.bmcl.2005.11.112
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823