Literature DB >> 16406142

Dimerization of the melanocortin 4 receptor: a study using bioluminescence resonance energy transfer.

Sarah A Nickolls1, Rich A Maki.   

Abstract

The melanocortin 4 receptor is important in the regulation of satiety. In this study we have investigated the propensity of the MC4 receptor to homodimerize. MC4 receptors with either a modified green fluorescent protein (GFP(2)) or Renilla luciferase (RLuc) at their C-terminus were constructed. These receptors showed equivalent binding and functional properties to the wild-type MC4 receptor. Bioluminescence resonance energy transfer readings indicated that the MC4 receptor exists as a constitutive homodimer, which was not regulated by peptide interaction. The efficiency of MC4 receptor to form homodimers was greatly enhanced compared to its ability to heterodimerize with the kappa opioid receptor.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16406142     DOI： 10.1016/j.peptides.2004.12.037

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  12 in total

Review 1.  Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.

Authors:  Mark D Ericson; Cody J Lensing; Katlyn A Fleming; Katherine N Schlasner; Skye R Doering; Carrie Haskell-Luevano
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2017-03-29       Impact factor: 5.187

2.  Synthesis and bioactivity of MSH4 oligomers prepared by an A2 + B2 strategy.

Authors:  Dilani Chathurika Dehigaspitiya; Suryakiran Navath; Craig S Weber; Ronald M Lynch; Eugene A Mash
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

3.  Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors.

Authors:  Cody J Lensing; Katie T Freeman; Sathya M Schnell; Robert C Speth; Adam T Zarth; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2018-05-09       Impact factor: 7.446

4.  The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.

Authors:  Ya-Xiong Tao
Journal:  Endocr Rev       Date:  2010-02-26       Impact factor: 19.871

5.  A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage.

Authors:  Cody J Lensing; Danielle N Adank; Stacey L Wilber; Katie T Freeman; Sathya M Schnell; Robert C Speth; Adam T Zarth; Carrie Haskell-Luevano
Journal:  ACS Chem Neurosci       Date:  2017-02-16       Impact factor: 4.418

6.  The multifaceted melanocortin receptors.

Authors:  Linda Laiho; Joanne Fiona Murray
Journal:  Endocrinology       Date:  2022-06-14       Impact factor: 5.051

7.  An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers.

Authors:  Cody J Lensing; Katie T Freeman; Sathya M Schnell; Danielle N Adank; Robert C Speth; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2016-03-29       Impact factor: 7.446

8.  Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.

Authors:  Julien A Sebag; Patricia M Hinkle
Journal:  J Biol Chem       Date:  2009-06-17       Impact factor: 5.157

9.  Bioluminescence resonance energy transfer reveals the adrenocorticotropin (ACTH)-induced conformational change of the activated ACTH receptor complex in living cells.

Authors:  Sadani N Cooray; Teng-Teng Chung; Khansa Mazhar; Laszlo Szidonya; Adrian J L Clark
Journal:  Endocrinology       Date:  2010-12-22       Impact factor: 4.736

Review 10.  Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor.

Authors:  Gunnar Kleinau; Nicolas A Heyder; Ya-Xiong Tao; Patrick Scheerer
Journal:  Int J Mol Sci       Date:  2020-08-10       Impact factor: 5.923
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.