| Literature DB >> 16406136 |
Hiromichi Katakura1, Kazumasa Takenaka, Masatsugu Nakagawa, Makoto Sonobe, Masashi Adachi, Shinya Ito, Hiromi Wada, Fumihiro Tanaka.
Abstract
Maspin is a member of the serpin (serine protease inhibitor) superfamily, and some experimental studies revealed a potential tumor suppressor activity of maspin. To reveal clinical significance of maspin status in non-small cell lung cancer (NSCLC), we quantitatively evaluated maspin gene expression in lung primary tumors cut from a total of 55 resected NSCLC patients. Maspin expression in squamous cell carcinoma (Sq) was significantly higher than that in adenocarcinoma (Ad, p=0.011). Five-year overall survival rates of maspin-high and maspin-low patients were 67.7 and 41.4%, respectively, demonstrating a significant favorable prognosis of maspin-high patients (log-rank, p=0.042). A multivariate analysis confirmed that high maspin expression was an independent and significant factor to predict a favorable overall survival (p=0.031). These results suggested that maspin expression was significantly increased in Sq than in Ad, and that increased maspin expression was a significant factor to predict a favorable prognosis in resected NSCLC.Entities:
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Year: 2006 PMID： 16406136 DOI： 10.1016/j.lungcan.2005.10.017
Source DB: PubMed Journal: Lung Cancer ISSN： 0169-5002 Impact factor: 5.705