Ivan D Miziara1, Bernardo C Araújo Filho, Raimar Weber. 1. Division of Clinical Otorhinolaryngology, Department of Otorhinolaryngology and Ophthalmology, Medical School, University of Sao Paulo, SP, Brazil. miz@uol.com.br
Abstract
INTRODUCTION: The advent of new antiretroviral drugs such as protease inhibitors (PI) has generated sensible changes in oral manifestation patterns in human immunodeficiency virus (HIV) infected adult patients. OBJECTIVES: The purpose of the present study was to assess whether the use of highly active antiretroviral therapy (HAART) has brought changes to pattern and prevalence of oral lesions related to HIV in the HIV-infected pediatric population. CASUISTIC AND METHOD: We analyzed medical charts of 471 children aged zero to 12 years and 11 months with HIV infection and followed up by the Ambulatory of AIDS, Clinical Otorhinolaryngology, Hospital das Clinicas, Medical School, Sao Paulo University, from January 1990 to December 2004. Four hundred and fifty-nine children were divided into two groups, according to age range: X (0-5 years and 11 months) and Y (6-12 years and 11 months). These groups were subdivided into four subgroups, according to use of ART (antiretroviral therapy without PI) or HAART. We recorded data related to type of oral lesion presented, as well as serum CD4+ lymphocyte count. The groups were compared concerning prevalence and presentation pattern of oral manifestations. RESULTS: Out of 459 children, 144 (31.4%) had oral lesions. We observed that in children aged 6-12 years and 11 months who were taking HAART, there was lower prevalence of oral lesions (p=0.005), specially hairy leukoplakia (p<0.02), without any affection to the common presentation pattern of these lesions. The same subgroup also had higher serum CD4+ lymphocyte counts (p<0.001). CONCLUSION: We concluded that use of HAART could lead to reduction in prevalence of oral lesions in HIV-infected children.
INTRODUCTION: The advent of new antiretroviral drugs such as protease inhibitors (PI) has generated sensible changes in oral manifestation patterns in human immunodeficiency virus (HIV) infected adultpatients. OBJECTIVES: The purpose of the present study was to assess whether the use of highly active antiretroviral therapy (HAART) has brought changes to pattern and prevalence of oral lesions related to HIV in the HIV-infected pediatric population. CASUISTIC AND METHOD: We analyzed medical charts of 471 children aged zero to 12 years and 11 months with HIV infection and followed up by the Ambulatory of AIDS, Clinical Otorhinolaryngology, Hospital das Clinicas, Medical School, Sao Paulo University, from January 1990 to December 2004. Four hundred and fifty-nine children were divided into two groups, according to age range: X (0-5 years and 11 months) and Y (6-12 years and 11 months). These groups were subdivided into four subgroups, according to use of ART (antiretroviral therapy without PI) or HAART. We recorded data related to type of oral lesion presented, as well as serum CD4+ lymphocyte count. The groups were compared concerning prevalence and presentation pattern of oral manifestations. RESULTS: Out of 459 children, 144 (31.4%) had oral lesions. We observed that in children aged 6-12 years and 11 months who were taking HAART, there was lower prevalence of oral lesions (p=0.005), specially hairy leukoplakia (p<0.02), without any affection to the common presentation pattern of these lesions. The same subgroup also had higher serum CD4+ lymphocyte counts (p<0.001). CONCLUSION: We concluded that use of HAART could lead to reduction in prevalence of oral lesions in HIV-infectedchildren.
Authors: Ana Lucia Seminario; Arthur Kemoli; Walter Fuentes; Yan Wang; Poojashree Rajanbabu; Dalton Wamalwa; Sarah Benki-Nugent; Grace John-Stewart; Jennifer A Slyker Journal: PLoS One Date: 2022-10-13 Impact factor: 3.752
Authors: Ana Lucia Seminario; Arthur Kemoli; Sarah Benki-Nugent; Daisy Chebet; Lauren Gomez; Dalton Wamalwa; Grace John-Stewart; Jennifer A Slyker Journal: Int J Paediatr Dent Date: 2021-03-23 Impact factor: 3.264