OBJECTIVES: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-gamma-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. STUDY DESIGN: Prospective study. METHODS: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P<0.05). CONCLUSIONS: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.
OBJECTIVES:Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-gamma-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. STUDY DESIGN: Prospective study. METHODS: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitispatients than in controls (P<0.05). CONCLUSIONS: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.
Authors: Samuel B Anyona; Prakasha Kempaiah; Evans Raballah; Collins Ouma; Tom Were; Gregory C Davenport; Stephen N Konah; John M Vulule; James B Hittner; Charity W Gichuki; John M Ong'echa; Douglas J Perkins Journal: Infect Immun Date: 2011-10-03 Impact factor: 3.441
Authors: K Manohar; P V Suneetha; Nirupama Trehan Pati; Abhishek C Gupta; Syed Hissar; Puja Sakhuja; S K Sarin Journal: Hepatol Int Date: 2009-03-17 Impact factor: 6.047
Authors: Ravinder S Natt; Petros D Karkos; Davinia K Natt; Eva G Theochari; Apostolos Karkanevatos Journal: BMC Ear Nose Throat Disord Date: 2011-04-11