Literature DB >> 16404527

An efficient synthesis of new C-2 aryl substituted quinolines based on three component imino Diels-Alder reaction.

Vladimir V Kouznetsov1, Arnold R Romero Bohórquez, Luis Astudillo Saavedra, Ricardo Fierro Medina.   

Abstract

New effective approach to the synthesis of a wide variety of C-2 nitro or aminophenyl substituted quinolines was reported using diverse intermediate 4-(2-oxopyrrolinidyl-1)-tetrahydroquinolines that were prepared by a three component imino Diels-Alder reaction was reported. The key aromatisation process occurs cleanly with the loss of the 2-oxopyrrolinidyl-1 fragment.

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Year:  2006        PMID： 16404527     DOI： 10.1007/s11030-006-2344-8

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  2 in total

1.  Inhibitors of the fungal cell wall. Synthesis of 4-aryl-4-N-arylamine-1-butenes and related compounds with inhibitory activities on beta(1-3) glucan and chitin synthases.

Authors:  J M Urbina; J C Cortés; A Palma; S N López; S A Zacchino; R D Enriz; J C Ribas; V V Kouznetzov
Journal:  Bioorg Med Chem       Date:  2000-04       Impact factor: 3.641

2.  New synthetic pathway to diverse 2-substituted quinolines based on a multicomponent reaction: solution-phase and solid-phase applications.

Authors:  Thierry Demaude; Laurent Knerr; Patrick Pasau
Journal:  J Comb Chem       Date:  2004 Sep-Oct
  2 in total
  4 in total

1.  Efficient synthesis and free-radical scavenging capacity of new 2,4-substituted tetrahydroquinolines prepared via BiCl₃-catalyzed three-component Povarov reaction, using N-vinylamides.

Authors:  Vladimir V Kouznetsov; Carlos M Meléndez Gómez; Luz K Luna Parada; John H Bermudez; Leonor Y Vargas Méndez; Amner Muñoz Acevedo
Journal:  Mol Divers       Date:  2011-09-25       Impact factor: 2.943

2.  Synthesis of dihydroisoindolo[2,1-a]quinolin-11-ones, their in silico ADMET properties and in vitro antitumor activities.

Authors:  Diego R Merchán-Arenas; Felipe Sojo; Francisco Arvelo; Vladimir V Kouznetsov
Journal:  RSC Adv       Date:  2020-11-19       Impact factor: 4.036

3.  Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes.

Authors:  Jing Sun; Hong Gao; Qun Wu; Chao-Guo Yan
Journal:  Beilstein J Org Chem       Date:  2012-10-26       Impact factor: 2.883

4.  Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.

Authors:  Francisco X Talamas; Sarah C Abbot; Shalini Anand; Ken A Brameld; David S Carter; Jun Chen; Dana Davis; Javier de Vicente; Amy D Fung; Leyi Gong; Seth F Harris; Petra Inbar; Sharada S Labadie; Eun K Lee; Remy Lemoine; Sophie Le Pogam; Vincent Leveque; Jim Li; Joel McIntosh; Isabel Nájera; Jaehyeon Park; Aruna Railkar; Sonal Rajyaguru; Michael Sangi; Ryan C Schoenfeld; Leanna R Staben; Yunchou Tan; Joshua P Taygerly; Armando G Villaseñor; Paul E Weller
Journal:  J Med Chem       Date:  2013-11-06       Impact factor: 7.446
  4 in total

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