OBJECTIVES: Pneumocystis pneumonia (PCP) is a severe opportunistic infection in immunosuppressed patients, caused by Pneumocystis jiroveci. The incidence among HIV negative patients is considered to have increased during the last decade. METHODS: We collected data retrospectively from the cases with PCP diagnosed at Sahlgrenska University Hospital between January 1991 and December 2001. RESULTS: 118 episodes of PCP were registered in 108 patients. The most common underlying immunosuppressions were HIV and solid organ transplantation with 29 and 26 cases, respectively. The number of PCP cases did not increase during the study period. Out of the 118 episodes of PCP 89 (75%) were in patients not infected with HIV. No clusters were found among HIV positive patients. We found 5 smaller clusters among non-HIV patients. Among the cases with proven PCP, 17% were on prophylaxis: 30% of the HIV infected patients and 13% of the non-HIV patients. CONCLUSIONS: The number of PCP cases is not increasing, 75% of the patients are HIV negative, Only 17% of the patients were on prophylaxis before the episode of PCP, indicating that not all patients at risk are identified.
OBJECTIVES:Pneumocystis pneumonia (PCP) is a severe opportunistic infection in immunosuppressed patients, caused by Pneumocystis jiroveci. The incidence among HIV negative patients is considered to have increased during the last decade. METHODS: We collected data retrospectively from the cases with PCP diagnosed at Sahlgrenska University Hospital between January 1991 and December 2001. RESULTS: 118 episodes of PCP were registered in 108 patients. The most common underlying immunosuppressions were HIV and solid organ transplantation with 29 and 26 cases, respectively. The number of PCP cases did not increase during the study period. Out of the 118 episodes of PCP 89 (75%) were in patients not infected with HIV. No clusters were found among HIV positive patients. We found 5 smaller clusters among non-HIV patients. Among the cases with proven PCP, 17% were on prophylaxis: 30% of the HIV infectedpatients and 13% of the non-HIV patients. CONCLUSIONS: The number of PCP cases is not increasing, 75% of the patients are HIV negative, Only 17% of the patients were on prophylaxis before the episode of PCP, indicating that not all patients at risk are identified.
Authors: Taylor Eddens; Waleed Elsegeiny; Michael P Nelson; William Horne; Brian T Campfield; Chad Steele; Jay K Kolls Journal: J Immunol Date: 2015-05-20 Impact factor: 5.422
Authors: Waleed Elsegeiny; Mingquan Zheng; Taylor Eddens; Richard L Gallo; Guixiang Dai; Giraldina Trevejo-Nunez; Patricia Castillo; Kara Kracinovsky; Hillary Cleveland; William Horne; Jonathan Franks; Derek Pociask; Mark Pilarski; John F Alcorn; Kong Chen; Jay K Kolls Journal: JCI Insight Date: 2018-06-21
Authors: Taylor Eddens; Waleed Elsegeiny; Maria de la Luz Garcia-Hernadez; Patricia Castillo; Giraldina Trevejo-Nunez; Katelin Serody; Brian T Campfield; Shabaana A Khader; Kong Chen; Javier Rangel-Moreno; Jay K Kolls Journal: Cell Rep Date: 2017-03-28 Impact factor: 9.423
Authors: Taylor Eddens; Brian T Campfield; Katelin Serody; Michelle L Manni; William Horne; Waleed Elsegeiny; Kevin J McHugh; Derek Pociask; Kong Chen; Mingquan Zheng; John F Alcorn; Sally Wenzel; Jay K Kolls Journal: Am J Respir Crit Care Med Date: 2016-10-01 Impact factor: 21.405
Authors: K M Williams; K W Ahn; M Chen; M D Aljurf; A L Agwu; A R Chen; T J Walsh; P Szabolcs; M J Boeckh; J J Auletta; C A Lindemans; J Zanis-Neto; M Malvezzi; J Lister; J S de Toledo Codina; K Sackey; J L H Chakrabarty; P Ljungman; J R Wingard; M D Seftel; S Seo; G A Hale; B Wirk; M S Smith; B N Savani; H M Lazarus; D I Marks; C Ustun; H Abdel-Azim; C C Dvorak; J Szer; J Storek; A Yong; M R Riches Journal: Bone Marrow Transplant Date: 2016-01-04 Impact factor: 5.483