M Aoki1, K Ando, B Kuze, K Mizuta, T Hayashi, Y Ito. 1. Otolaryngology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, Gifu 501-1194, Japan. aoki@cc.gifu-u.ac.jp
Abstract
OBJECTIVES: An elevation of the plasma antidiuretic hormone (ADH) levels has frequently been observed in Meniere's disease patients. However, little is known regarding the mechanism behind such an elevation of ADH level in Meniere's disease patients. Therefore, we measured the plasma ADH in Meniere's disease patients and other vertigo patients to elucidate the association between the ADH levels, stress levels and the development of Meniere's symptom. DESIGN AND SETTING: The plasma ADH levels and plasma osmotic pressure were determined in 23 definite Meniere's disease patients and 160 patients with other types of vertigo/dizziness. All participants were administered questionnaire regarding their psychological status including their stress levels. RESULTS: The ADH levels of Meniere's disease patients in the acute phase (5.80 +/- 1.37 pg/mL) were significantly higher in comparison with that of Meniere's disease patients in the remission phase (2.26 +/- 0.41 pg/mL) (P < 0.05). In other peripheral vertigo patients, the ADH level in the acute phase (1.71 +/- 0.23 pg/mL) was not significantly different from that in the remission phase (1.45 +/- 0.15 pg/mL). Meniere's disease patients in the acute phase had a significantly higher stress score (114 +/- 23) than Meniere's disease patients in the remission phase (56 +/- 13) (P < 0.05). However, there was no significant correlation between their stress score and the ADH levels. CONCLUSIONS: These results suggest that the elevation of the plasma ADH levels in Meniere's disease patients in the acute phase is, therefore, associated with the pathogenesis of Meniere's disease attacks rather than with stress.
OBJECTIVES: An elevation of the plasma antidiuretic hormone (ADH) levels has frequently been observed in Meniere's diseasepatients. However, little is known regarding the mechanism behind such an elevation of ADH level in Meniere's diseasepatients. Therefore, we measured the plasma ADH in Meniere's diseasepatients and other vertigopatients to elucidate the association between the ADH levels, stress levels and the development of Meniere's symptom. DESIGN AND SETTING: The plasma ADH levels and plasma osmotic pressure were determined in 23 definite Meniere's diseasepatients and 160 patients with other types of vertigo/dizziness. All participants were administered questionnaire regarding their psychological status including their stress levels. RESULTS: The ADH levels of Meniere's diseasepatients in the acute phase (5.80 +/- 1.37 pg/mL) were significantly higher in comparison with that of Meniere's diseasepatients in the remission phase (2.26 +/- 0.41 pg/mL) (P < 0.05). In other peripheral vertigopatients, the ADH level in the acute phase (1.71 +/- 0.23 pg/mL) was not significantly different from that in the remission phase (1.45 +/- 0.15 pg/mL). Meniere's diseasepatients in the acute phase had a significantly higher stress score (114 +/- 23) than Meniere's diseasepatients in the remission phase (56 +/- 13) (P < 0.05). However, there was no significant correlation between their stress score and the ADH levels. CONCLUSIONS: These results suggest that the elevation of the plasma ADH levels in Meniere's diseasepatients in the acute phase is, therefore, associated with the pathogenesis of Meniere's disease attacks rather than with stress.
Authors: A Eckhard; A Dos Santos; W Liu; M Bassiouni; H Arnold; C Gleiser; B Hirt; C Harteneck; M Müller; H Rask-Andersen; H Löwenheim Journal: Pflugers Arch Date: 2015-07-25 Impact factor: 3.657
Authors: Daniel Runggaldier; Lidia Garcia Pradas; Peter H Neckel; Andreas F Mack; Bernhard Hirt; Corinna Gleiser Journal: Sci Rep Date: 2017-04-04 Impact factor: 4.379