Literature DB >> 1640170

Monoclonal antibody NIMP-R10 directed against the CD11b chain of the type 3 complement receptor can substitute for monoclonal antibody 5C6 to exacerbate listeriosis by preventing the focusing of myelomonocytic cells at infectious foci in the liver.

J W Conlan1, R J North.   

Abstract

Treatment of mice with a monoclonal antibody (mAb) designated NIMP-R10, directed against the CD11b polypeptide of the CD18/CD11b heterodimeric type 3 complement receptor (CR3), exacerbates listeriosis by preventing myelomonocytic cells from focusing at sites of infected hepatocytes in the liver. Under these conditions an otherwise sublethal Listeria inoculum grows unrestrictedly within hepatocytes and causes death in 3 days. The results obtained with NIMP-R10 are similar to those previously obtained with a different anti-CD11b mAb (5C6), although mAb NIMP-R10 is more effective at enhancing infection. Therefore, both mAbs can be used to analyze host antibacterial defenses in vivo.

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Year:  1992        PMID： 1640170     DOI： 10.1002/jlb.52.1.130

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  9 in total

1.  Leukocyte-mediated lysis of infected hepatocytes during listeriosis occurs in mice depleted of NK cells or CD4+ CD8+ Thy1.2+ T cells.

Authors:  J W Conlan; P L Dunn; R J North
Journal:  Infect Immun       Date:  1993-06       Impact factor: 3.441

2.  A novel IL-17-dependent mechanism of cross protection: respiratory infection with mycoplasma protects against a secondary listeria infection.

Authors:  Amy N Sieve; Karen D Meeks; Sheetal Bodhankar; Suheung Lee; Jay K Kolls; Jerry W Simecka; Rance E Berg
Journal:  Eur J Immunol       Date:  2009-02       Impact factor: 5.532

3.  Early pathogenesis of infection in the liver with the facultative intracellular bacteria Listeria monocytogenes, Francisella tularensis, and Salmonella typhimurium involves lysis of infected hepatocytes by leukocytes.

Authors:  J W Conlan; R J North
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

4.  Listeria monocytogenes, but not Salmonella typhimurium, elicits a CD18-independent mechanism of neutrophil extravasation into the murine peritoneal cavity.

Authors:  J W Conlan; R J North
Journal:  Infect Immun       Date:  1994-07       Impact factor: 3.441

5.  Defense mechanisms in Peyer's patches and mesenteric lymph nodes against Yersinia enterocolitica involve integrins and cytokines.

Authors:  I B Autenrieth; V Kempf; T Sprinz; S Preger; A Schnell
Journal:  Infect Immun       Date:  1996-04       Impact factor: 3.441

6.  Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr.

Authors:  C A Lowell; G Berton
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-23       Impact factor: 11.205

7.  In vivo involvement of polymorphonuclear neutrophils in Leishmania infantum infection.

Authors:  D Rousseau; S Demartino; B Ferrua; J F Michiels; F Anjuère; K Fragaki; Y Le Fichoux; J Kubar
Journal:  BMC Microbiol       Date:  2001-08-17       Impact factor: 3.605

8.  Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody.

Authors:  J W Conlan; R J North
Journal:  J Exp Med       Date:  1994-01-01       Impact factor: 14.307

9.  Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin.

Authors:  Aline Dupont; Fatima Mohamed; Nur'Ain Salehen; Sarah Glenn; Lorenza Francescut; Rozita Adib; Simon Byrne; Hannah Brewin; Irina Elliott; Luke Richards; Petya Dimitrova; Wilhelm Schwaeble; Nina Ivanovska; Aras Kadioglu; Lee R Machado; Peter W Andrew; Cordula Stover
Journal:  Med Microbiol Immunol       Date:  2014-04-12       Impact factor: 3.402
  9 in total

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