AIMS: To determine whether sex differences of in-hospital and after-discharge mortality differ according to the age. METHODS AND RESULTS: Data of 4347 consecutive patients hospitalized within 48 h of the onset of acute myocardial infarction (AMI) were analysed. Patients were classified according to median age (68 years): Group 1 (G1) (308 women, 30-67 years), G2 (1878 men, 30-67 years), G3 (860 women, 68-89 years), and G4 (1301 men, 68-89 years). In both age groups, women were older, had more frequent co-morbidities, lower rate of reperfusion therapy, and received less anti-platelet agents, beta-blockers, and statins than men. The overall 1-year mortality was higher in women (25% vs. 16% in men, P<0.0001). After adjustment, in-hospital mortality was higher only for the women in the younger age group. (G1 vs. G2: OR=2.2, 95%CI=1.3-3.8; G3 vs. G4: OR=1.1, 95%CI=the risk of death, after hospital discharge, was no longer related to gender in any age group. CONCLUSION: The higher 1-year mortality following AMI in women is explained by the higher risk of death in young women during the first days of hospitalization. Further investigations are crucial to determine the cause in order to improve the chance of survival in younger women.
AIMS: To determine whether sex differences of in-hospital and after-discharge mortality differ according to the age. METHODS AND RESULTS: Data of 4347 consecutive patients hospitalized within 48 h of the onset of acute myocardial infarction (AMI) were analysed. Patients were classified according to median age (68 years): Group 1 (G1) (308 women, 30-67 years), G2 (1878 men, 30-67 years), G3 (860 women, 68-89 years), and G4 (1301 men, 68-89 years). In both age groups, women were older, had more frequent co-morbidities, lower rate of reperfusion therapy, and received less anti-platelet agents, beta-blockers, and statins than men. The overall 1-year mortality was higher in women (25% vs. 16% in men, P<0.0001). After adjustment, in-hospital mortality was higher only for the women in the younger age group. (G1 vs. G2: OR=2.2, 95%CI=1.3-3.8; G3 vs. G4: OR=1.1, 95%CI=the risk of death, after hospital discharge, was no longer related to gender in any age group. CONCLUSION: The higher 1-year mortality following AMI in women is explained by the higher risk of death in young women during the first days of hospitalization. Further investigations are crucial to determine the cause in order to improve the chance of survival in younger women.
Authors: Hanna-Riikka Lehto; Seppo Lehto; Aki Samuli Havulinna; Matti Ketonen; Aapo Lehtonen; Yrjö Antero Kesäniemi; Kari Juhani Airaksinen; Veikko Salomaa Journal: Eur J Epidemiol Date: 2011-06-30 Impact factor: 8.082
Authors: Rachel P Dreyer; Christopher Sciria; Erica S Spatz; Basmah Safdar; Gail D'Onofrio; Harlan M Krumholz Journal: Circ Cardiovasc Qual Outcomes Date: 2017-02-22
Authors: Lulu Li; Xiling Zhang; Yini Wang; Xi Yu; Haibo Jia; Jingbo Hou; Chunjie Li; Wenjuan Zhang; Wei Yang; Bin Liu; Lixin Lu; Ning Tan; Bo Yu; Kang Li Journal: Front Cardiovasc Med Date: 2022-04-07
Authors: Xin Zheng; Rachel P Dreyer; Shuang Hu; Erica S Spatz; Frederick A Masoudi; John A Spertus; Khurram Nasir; Xi Li; Jing Li; Sisi Wang; Harlan M Krumholz; Lixin Jiang Journal: Heart Date: 2014-12-15 Impact factor: 5.994
Authors: Tina K Gonzales; James A Yonker; Vicky Chang; Carol L Roan; Pamela Herd; Craig S Atwood Journal: BMJ Open Date: 2017-01-23 Impact factor: 2.692