Gabi Zeilig1, Harold P Weingarden, Richard Levy, Inbal Peer, Avi Ohry, Nava Blumen. 1. Department of Neurological Rehabilitation, Chaim Sheba Medical Center, Tel Hashomer; and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. gavriel.zeilig@sheba.health.gov.il
Abstract
OBJECTIVE: To define the incidence, effects on functional abilities, and possible causation of heterotopic ossification (HO) in Guillain-Barré syndrome (GBS) patients admitted for inpatient rehabilitation. DESIGN: Long-term prospective study on neurologic and functional outcome of GBS patients admitted for rehabilitation. SETTING: Rehabilitation department, inpatient and outpatient, within a university-affiliated medical center. PARTICIPANTS: All GBS patients admitted for rehabilitation and followed for a minimum of 3 years. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Presence of HO, factors that may be etiologically significant, and effects on functionality. Data included: medical interventions, Disability Grading Scale, need for assisted ventilation, electrodiagnostic findings, autonomic function, standard neuro-musculo-skeletal evaluation, and hospital length of stay. RESULTS: Four (6%) of 65 patients had HO, 24 of whom required mechanical ventilation. All had decreased range of motion in the involved hips that affected mobility. CONCLUSIONS: Even though it has been rarely reported, HO does occur in GBS and affects functional outcome.
OBJECTIVE: To define the incidence, effects on functional abilities, and possible causation of heterotopic ossification (HO) in Guillain-Barré syndrome (GBS) patients admitted for inpatient rehabilitation. DESIGN: Long-term prospective study on neurologic and functional outcome of GBSpatients admitted for rehabilitation. SETTING: Rehabilitation department, inpatient and outpatient, within a university-affiliated medical center. PARTICIPANTS: All GBSpatients admitted for rehabilitation and followed for a minimum of 3 years. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Presence of HO, factors that may be etiologically significant, and effects on functionality. Data included: medical interventions, Disability Grading Scale, need for assisted ventilation, electrodiagnostic findings, autonomic function, standard neuro-musculo-skeletal evaluation, and hospital length of stay. RESULTS: Four (6%) of 65 patients had HO, 24 of whom required mechanical ventilation. All had decreased range of motion in the involved hips that affected mobility. CONCLUSIONS: Even though it has been rarely reported, HO does occur in GBS and affects functional outcome.