[Peculiarities of hepatic experimental wound healing in rats treated with angiogenin].

Gel, containing recombinant human angiogenin (0.1 ml), was applied upon the injured liver (experimental wedge-shaped resection) of adult rats. Histological study has demonstrated that in animals treated with angiogenin, the zone of purulent-necrotic inflammation was reduced at already the early stages of an experiment, while by day 7 the scar was formed that was represented by a mature connective tissue free from inflammatory phenomena. Increased number of binucleate hepatocytes, positive time course of mononuclear hepatocyte/degenerating cell ratio also indicate the stimulation of regeneration processes in rat liver parenchyma, that is corroborated by the results of biochemical analysis of blood.