OBJECTIVE: To investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion SPECT images (BSI) from patients with temporal lobe epilepsy (TLE). METHOD: It was acquired interictal and ictal BSI from 24 patients with refractory TLE. BSIs were analyzed by visual inspection and statistical parametric mapping (SPM2). Statistical analysis compared the patients group to a control group of 50 volunteers. The images from patients with left-TLE were left-right flipped. RESULTS: It was not observed significant perfusional differences in interictal scans with SPM. Ictal BSI in SPM analysis revealed hyperperfusion within ipsilateral temporal lobe (epileptogenic focus) and also contralateral parieto-occipital region, ipsilateral posterior cingulate gyrus, occipital lobes and ipsilateral basal ganglia. Ictal BSI also showed areas of hypoperfusion. CONCLUSION: In a group analysis of ictal BSI of patients with TLE, voxel-wise analysis detects a network of distant regions of perfusional alteration which may play active role in seizure genesis and propagation.
OBJECTIVE: To investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion SPECT images (BSI) from patients with temporal lobe epilepsy (TLE). METHOD: It was acquired interictal and ictal BSI from 24 patients with refractory TLE. BSIs were analyzed by visual inspection and statistical parametric mapping (SPM2). Statistical analysis compared the patients group to a control group of 50 volunteers. The images from patients with left-TLE were left-right flipped. RESULTS: It was not observed significant perfusional differences in interictal scans with SPM. Ictal BSI in SPM analysis revealed hyperperfusion within ipsilateral temporal lobe (epileptogenic focus) and also contralateral parieto-occipital region, ipsilateral posterior cingulate gyrus, occipital lobes and ipsilateral basal ganglia. Ictal BSI also showed areas of hypoperfusion. CONCLUSION: In a group analysis of ictal BSI of patients with TLE, voxel-wise analysis detects a network of distant regions of perfusional alteration which may play active role in seizure genesis and propagation.
Authors: Maarten Haemels; Donatienne Van Weehaeghe; Evy Cleeren; Patrick Dupont; Johan van Loon; Tom Theys; Koen Van Laere; Wim Van Paesschen; Karolien Goffin Journal: Acta Neurol Belg Date: 2021-02-05 Impact factor: 2.396
Authors: Leonardo Deus-Silva; Leonardo Bonilha; Benito P Damasceno; Andre L F Costa; Clarissa L Yasuda; Fernando F Costa; Allan O Santos; Elba C S C Etchebehere; Regis Oquendo-Nogueira; Renata Fockink; Claudio Fróes de Freitas; Edwaldo E Camargo; Li M Li; Fernando Cendes; Sara T Saad Journal: Front Neurol Date: 2013-12-20 Impact factor: 4.003
Authors: Karen M Sequeira; Ali Tabesh; Rup K Sainju; Stacia M DeSantis; Thomas Naselaris; Jane E Joseph; Mark A Ahlman; Kenneth M Spicer; Steve S Glazier; Jonathan C Edwards; Leonardo Bonilha Journal: PLoS One Date: 2013-01-14 Impact factor: 3.240