| Literature DB >> 16399578 |
Stanley R Riddell1, Marie Bleakley, Tetsuya Nishida, Carolina Berger, Edus H Warren.
Abstract
Animal models and human studies of allogeneic hematopoietic cell transplantation (HCT) demonstrate that immunologic nonidentity between donor and recipient is responsible for a graft versus leukemia (GVL) effect that contributes to complete tumor eradication. A variety of immune cells have been implicated in the GVL effect including NK cells, B cells, and CD4(+) and CD8(+) T cells that recognize minor histocompatibility (H) or leukemia-associated antigens. Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect.Entities:
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Year: 2006 PMID： 16399578 DOI： 10.1016/j.bbmt.2005.10.025
Source DB: PubMed Journal: Biol Blood Marrow Transplant ISSN： 1083-8791 Impact factor: 5.742