Literature DB >> 16399556

Dermal regeneration template in the surgical management of diabetic foot ulcers: a series of five cases.

Glenn Silverstein1.   

Abstract

Soft-tissue defects in the feet of patients with diabetes continue to pose a challenge because adequate debridement often leaves an extensive defect with exposed bone, tendon, and cartilage. The use of a dermal regeneration template followed by split-thickness skin grafts in the treatment of recalcitrant diabetic foot wounds was retrospectively reviewed. In a case series of 5 patients with diabetes and extensive tissue deficits of the foot, the use of a dermal regeneration template and split-thickness skin graft enabled closure of the lower-extremity defect. All patients completely healed and were able to resume ambulation with the aid of extradepth shoes and multidensity insoles. The take of the dermal regeneration template was excellent in all patients, and the grafts (dermal regeneration templates and split-thickness skin) were durable even when placed on difficult areas such as the plantar surface and heel. No infections occurred. Exposed bone, tendon, cartilage, and fascia were successfully covered. The experience in this case series suggests that the use of the dermal regeneration template followed by split-thickness skin graft offers an option for patients with diabetes with chronic wounds that have foot defects as a result of extensive tissue loss resulting from infection.

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Year:  2006        PMID: 16399556     DOI: 10.1053/j.jfas.2005.10.005

Source DB:  PubMed          Journal:  J Foot Ankle Surg        ISSN: 1067-2516            Impact factor:   1.286


  9 in total

Review 1.  A review of tissue-engineered skin bioconstructs available for skin reconstruction.

Authors:  Rostislav V Shevchenko; Stuart L James; S Elizabeth James
Journal:  J R Soc Interface       Date:  2009-10-28       Impact factor: 4.118

2.  Soft Tissue Reconstructions with Dermal Substitutes Versus Alternative Approaches in Patients with Traumatic Complex Wounds.

Authors:  Umberto Morozzo; Jorge Hugo Villafañe; Giandavide Ieropoli; Silvia Chiara Zompi; Joshua A Cleland; Massimo Navissano; Fabrizio Malan
Journal:  Indian J Surg       Date:  2015-01-24       Impact factor: 0.656

3.  Compared to coverage by STSG grafts only reconstruction by the dermal substitute Integra® plus STSG increases TcPO2 values in diabetic feet at 3 and 6 months after reconstruction*.

Authors:  G Papa; L Spazzapan; M Pangos; A Delpin; Z M Arnez
Journal:  G Chir       Date:  2014 May-Jun

4.  The use of split-thickness skin grafts on diabetic foot ulcerations: a literature review.

Authors:  Brant McCartan; Thanh Dinh
Journal:  Plast Surg Int       Date:  2012-05-14

5.  A Novel and Alternative Treatment Method for Diabetic Heel Ulceration Exposing the Calcaneus Which Is Not Suitable for Flap Surgery: Vacuum Assisted Sandwich Dermal Matrix.

Authors:  Ugur A Bingol; Can Cinar; Hakan Arslan; Muzaffer Altındas
Journal:  Biomed Res Int       Date:  2015-09-21       Impact factor: 3.411

Review 6.  Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration.

Authors:  Qian Hua Phua; Hua Alexander Han; Boon-Seng Soh
Journal:  J Transl Med       Date:  2021-02-18       Impact factor: 5.531

7.  Long-term follow-up comparison of two different bi-layer dermal substitutes in tissue regeneration: Clinical outcomes and histological findings.

Authors:  Barbara De Angelis; Fabrizio Orlandi; Margarida Fernandes Lopes Morais D'Autilio; Maria G Scioli; Augusto Orlandi; Valerio Cervelli; Pietro Gentile
Journal:  Int Wound J       Date:  2018-03-28       Impact factor: 3.315

Review 8.  Wound Healing: Biologics, Skin Substitutes, Biomembranes and Scaffolds.

Authors:  Krishna S Vyas; Henry C Vasconez
Journal:  Healthcare (Basel)       Date:  2014-09-10

Review 9.  Naturally Occurring Extracellular Matrix Scaffolds for Dermal Regeneration: Do They Really Need Cells?

Authors:  A M Eweida; M K Marei
Journal:  Biomed Res Int       Date:  2015-10-05       Impact factor: 3.411

  9 in total

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