Literature DB >> 16399497

New drugs from fat bugs?

Evan D Rosen1.   

Abstract

Signal transduction cascades, such as Hedgehog (Hh) signaling, are potentially important targets for new drugs. A new study in this issue of Cell Metabolism identifies hedgehog signaling in the formation of the Drosophila fly body and in mammalian adipogenesis.

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Year:  2006        PMID: 16399497     DOI: 10.1016/j.cmet.2005.12.002

Source DB:  PubMed          Journal:  Cell Metab        ISSN: 1550-4131            Impact factor:   27.287


  3 in total

1.  Adipose is a conserved dosage-sensitive antiobesity gene.

Authors:  Jae Myoung Suh; Daniel Zeve; Renee McKay; Jin Seo; Zack Salo; Robert Li; Michael Wang; Jonathan M Graff
Journal:  Cell Metab       Date:  2007-09       Impact factor: 27.287

2.  RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.

Authors:  Dagan Jenkins; Dominik Seelow; Fernanda S Jehee; Chad A Perlyn; Luis G Alonso; Daniela F Bueno; Dian Donnai; Dragana Josifova; Dragana Josifiova; Irene M J Mathijssen; Jenny E V Morton; Karen Helene Orstavik; Elizabeth Sweeney; Steven A Wall; Jeffrey L Marsh; Peter Nurnberg; Maria Rita Passos-Bueno; Andrew O M Wilkie
Journal:  Am J Hum Genet       Date:  2007-04-18       Impact factor: 11.025

3.  Reduced white fat mass in adult mice bearing a truncated Patched 1.

Authors:  Zili Li; Heng Zhang; Leslie A Denhard; Lan-Hsin Liu; Huaxin Zhou; Zi-Jian Lan
Journal:  Int J Biol Sci       Date:  2008-01-26       Impact factor: 6.580

  3 in total

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