Literature DB >> 16397805

[The early history of "Ecstasy"].

U Benzenhöfer1, T Passie.   

Abstract

There is no consensus in the literature regarding the early history of MDMA (Methylendioxymethamphetamine, so-called "Ecstasy"). Various authors credit the first synthesis of MDMA to the German chemist Fritz Haber, but it appears neither in his doctoral thesis (Berlin 1891) nor in his accompanying articles. The man who first synthesized MDMA was the chemist Dr. Anton Köllisch, who worked for the German pharmaceutical company Merck. He created MDMA as a by-product while trying to synthesize hydrastinin, a styptic substance. In 1912, Merck filed to patent the applied method of preparation. The patent was issued in 1914, yet no pharmaceutical testing followed at that time.

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Year:  2006        PMID: 16397805     DOI: 10.1007/s00115-005-2001-y

Source DB:  PubMed          Journal:  Nervenarzt        ISSN: 0028-2804            Impact factor:   1.214


  5 in total

Review 1.  Ecstasy (3,4-methylenedioxymethamphetamine): history, neurochemistry, and toxicology.

Authors:  J A Rochester; J T Kirchner
Journal:  J Am Board Fam Pract       Date:  1999 Mar-Apr

Review 2.  An exploration of the history and controversies surrounding MDMA and MDA.

Authors:  A R Pentney
Journal:  J Psychoactive Drugs       Date:  2001 Jul-Sep

Review 3.  The background and chemistry of MDMA.

Authors:  A T Shulgin
Journal:  J Psychoactive Drugs       Date:  1986 Oct-Dec

Review 4.  [Entactogenic drugs "ecstasy" (MDMA), "eve" (MDE) and other ring-substituted methamphetamine derivatives. A new class of substances among illegal designer drugs?].

Authors:  E Gouzoulis-Mayfrank; L Hermle; K A Kovar; H Sass
Journal:  Nervenarzt       Date:  1996-05       Impact factor: 1.214

5.  Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity.

Authors:  A C Parrott
Journal:  Psychopharmacology (Berl)       Date:  2004-03-09       Impact factor: 4.530

  5 in total
  5 in total

Review 1.  A developmental comparison of the neurobehavioral effects of ecstasy (MDMA).

Authors:  Brian J Piper
Journal:  Neurotoxicol Teratol       Date:  2006-10-20       Impact factor: 3.763

2.  The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study.

Authors:  Michael C Mithoefer; Mark T Wagner; Ann T Mithoefer; Lisa Jerome; Rick Doblin
Journal:  J Psychopharmacol       Date:  2010-07-19       Impact factor: 4.153

3.  MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology.

Authors:  P Sáez-Briones; A Hernández
Journal:  Curr Neuropharmacol       Date:  2013-09       Impact factor: 7.363

4.  Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders.

Authors:  Peter Oehen; Peter Gasser
Journal:  Front Psychiatry       Date:  2022-04-25       Impact factor: 4.157

5.  Current Perspective on MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder.

Authors:  Sascha B Thal; Miriam J J Lommen
Journal:  J Contemp Psychother       Date:  2018-01-06
  5 in total

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