| Literature DB >> 16395129 |
Yu-Li Liu1, Cathy Shen-Jang Fann, Chih-Min Liu, Jer-Yuarn Wu, Shuen-Iu Hung, Hung-Yu Chan, Jiahn-Jyh Chen, Chia-Ching Pan, Shih-Kai Liu, Ming H Hsieh, Tzung-Jeng Hwang, Wen-Chen Ouyang, Chun-Ying Chen, Jin-Jia Lin, Frank Huang-Chih Chou, Ching-Mo Chueh, Wei-Ming Liu, Ming-Ming Tsuang, Stephen V Faraone, Ming T Tsuang, Wei J Chen, Hai-Gwo Hwu.
Abstract
AKT1 (V-akt murine thymoma viral oncogene homolog 1) is a protein kinase isoform of AKT. Five single-nucleotide polymorphisms, rs3803300, rs1130214, rs3730358, rs2498799 and rs2494732, at the genomic region of AKT1 have been reported to be significantly associated with schizophrenia. We tested for the presence of these five single-nucleotide polymorphisms in a Taiwanese population by genotyping 218 co-affected schizophrenia families. Both single locus and haplotypes analyses showed no association of these single-nucleotide polymorphisms with schizophrenia. These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population.Entities:
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Year: 2006 PMID： 16395129 DOI： 10.1097/01.ypg.0000180681.80546.f3
Source DB: PubMed Journal: Psychiatr Genet ISSN： 0955-8829 Impact factor: 2.458