Literature DB >> 16394660

MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure.

Rikinari Hanayama1, Kay Miyasaka, Michio Nakaya, Shigekazu Nagata.   

Abstract

Apoptotic cells are swiftly engulfed by macrophages and immature dendritic cells. Inefficient clearance of apoptotic cells has been implicated as a cause of inflammation and autoimmune diseases. Milk fat globule-EGF factor 8 (MFG-E8) and developmental endothelial locus-1 (Del-1) are glycoproteins secreted from macrophages that pass apoptotic cells to phagocytes. MFG-E8, but not Del-1, is expressed in the tingible-body macrophages at the germinal centers of the second lymphoid tissues. MFG-E8-deficient mice carry many unengulfed apoptotic cells in the germinal centers of the spleen, and develop a lupus-like autoimmune disease. In this review, we discuss the importance of the MFG-E8-mediated clearance of apoptotic cells in the prevention of autoimmune diseases.

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Year:  2006        PMID： 16394660     DOI： 10.1159/000090780

Source DB:  PubMed          Journal:  Curr Dir Autoimmun        ISSN： 1422-2132


  26 in total

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2.  Deficiency in milk fat globule-epidermal growth factor-factor 8 exacerbates organ injury and mortality in neonatal sepsis.

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Review 3.  Autoantigens in systemic autoimmunity: critical partner in pathogenesis.

Authors:  A Rosen; L Casciola-Rosen
Journal:  J Intern Med       Date:  2009-06       Impact factor: 8.989

4.  Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans.

Authors:  Victor Venegas; Zheng Zhou
Journal:  Mol Biol Cell       Date:  2007-06-13       Impact factor: 4.138

Review 5.  Regulation of phagocytosis by Rho GTPases.

Authors:  Yingyu Mao; Silvia C Finnemann
Journal:  Small GTPases       Date:  2015-05-05

Review 6.  Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways.

Authors:  Kodi S Ravichandran
Journal:  Immunity       Date:  2011-10-28       Impact factor: 31.745

7.  Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice.

Authors:  Akihisa Matsuda; Rongqian Wu; Asha Jacob; Hidefumi Komura; Mian Zhou; Zhimin Wang; Md Monowar Aziz; Ping Wang
Journal:  Crit Care Med       Date:  2011-09       Impact factor: 7.598

8.  MFG-E8 regulates microglial phagocytosis of apoptotic neurons.

Authors:  Abby D Fuller; Linda J Van Eldik
Journal:  J Neuroimmune Pharmacol       Date:  2008-08-01       Impact factor: 4.147

9.  Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells.

Authors:  Thomas Enzler; Silke Gillessen; Michael Dougan; James P Allison; Donna Neuberg; Darryl A Oble; Martin Mihm; Glenn Dranoff
Journal:  Blood       Date:  2007-05-04       Impact factor: 22.113

10.  A pathway for phagosome maturation during engulfment of apoptotic cells.

Authors:  Jason M Kinchen; Kimon Doukoumetzidis; Johann Almendinger; Lilli Stergiou; Annie Tosello-Trampont; Costi D Sifri; Michael O Hengartner; Kodi S Ravichandran
Journal:  Nat Cell Biol       Date:  2008-04-20       Impact factor: 28.824
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