BACKGROUND: Exposure to environmental carcinogens leads to oral squamous cell carcinoma (OSCC); however, the impact of genetic variations in carcinogen metabolisms and DNA repair on OSCC risk considering environmental exposures has not been clearly elucidated. METHODS: We conducted a case-control study with 122 cases and 241 controls. The risk of OSCC was evaluated in 10 genetic polymorphisms of nine genes, such as CYP1A1, CYP2E1, GSTM1, GSTT1, XPA, XPC, XPC, XPF and ERCC1. Gene-environment interaction was also evaluated. RESULTS: We found that CYP2E1 and XPA polymorphisms significantly affected the OSCC risk. Gene-environment interactions with smoking were significant for CYP2E1 and ERCC1 polymorphisms. Odds ratios for gene-environment interaction were 7.98 (P = 0.036), 9.67 (P = 0.017) and 8.49 (P = 0.031) for CYP2E1RsaI, DraI and ERCC1 polymorphisms, respectively. No interaction was observed with heavy drinking and any polymorphisms. CONCLUSION: CYP2E1, XPA and ERCC1 polymorphisms may affect the risk of OSCC.
BACKGROUND: Exposure to environmental carcinogens leads to oral squamous cell carcinoma (OSCC); however, the impact of genetic variations in carcinogen metabolisms and DNA repair on OSCC risk considering environmental exposures has not been clearly elucidated. METHODS: We conducted a case-control study with 122 cases and 241 controls. The risk of OSCC was evaluated in 10 genetic polymorphisms of nine genes, such as CYP1A1, CYP2E1, GSTM1, GSTT1, XPA, XPC, XPC, XPF and ERCC1. Gene-environment interaction was also evaluated. RESULTS: We found that CYP2E1 and XPA polymorphisms significantly affected the OSCC risk. Gene-environment interactions with smoking were significant for CYP2E1 and ERCC1 polymorphisms. Odds ratios for gene-environment interaction were 7.98 (P = 0.036), 9.67 (P = 0.017) and 8.49 (P = 0.031) for CYP2E1RsaI, DraI and ERCC1 polymorphisms, respectively. No interaction was observed with heavy drinking and any polymorphisms. CONCLUSION:CYP2E1, XPA and ERCC1 polymorphisms may affect the risk of OSCC.
Authors: Marni Stott-Miller; Chu Chen; Shu-Chun Chuang; Yuan-Chin Amy Lee; Stefania Boccia; Hermann Brenner; Gabriela Cadoni; Luigino Dal Maso; Carlo La Vecchia; Philip Lazarus; Fabio Levi; Keitaro Matsuo; Hal Morgenstern; Heiko Müller; Joshua Muscat; Andrew F Olshan; Mark P Purdue; Diego Serraino; Thomas L Vaughan; Zuo-Feng Zhang; Paolo Boffetta; Mia Hashibe; Stephen M Schwartz Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-12-05 Impact factor: 4.254
Authors: Faraz Bishehsari; Lijuan Zhang; Robin M Voigt; Natalie Maltby; Bita Semsarieh; Eyas Zorub; Maliha Shaikh; Sherry Wilber; Andrew R Armstrong; Seyed Sina Mirbagheri; Nailliw Z Preite; Peter Song; Alessia Stornetta; Silvia Balbo; Christopher B Forsyth; Ali Keshavarzian Journal: Alcohol Clin Exp Res Date: 2019-07-22 Impact factor: 3.455