Literature DB >> 16392788

Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.

Ravindranadh V Somu1, Helena Boshoff, Chunhua Qiao, Eric M Bennett, Clifton E Barry, Courtney C Aldrich.   

Abstract

A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC(99) = 0.19 microM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.

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Year:  2006        PMID： 16392788     DOI： 10.1021/jm051060o

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  77 in total

1.  A continuous kinetic assay for adenylation enzyme activity and inhibition.

Authors:  Daniel J Wilson; Courtney C Aldrich
Journal:  Anal Biochem       Date:  2010-05-05       Impact factor: 3.365

2.  Predictive models for nucleoside bisubstrate analogs as inhibitors of siderophore biosynthesis in Mycobacterium tuberculosis: pharmacophore mapping and chemometric QSAR study.

Authors:  Nilesh R Tawari; Mariam S Degani
Journal:  Mol Divers       Date:  2010-03-21       Impact factor: 2.943

3.  Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.

Authors:  Garrett C Moraski; Mayland Chang; Adriel Villegas-Estrada; Scott G Franzblau; Ute Möllmann; Marvin J Miller
Journal:  Eur J Med Chem       Date:  2010-01-14       Impact factor: 6.514

4.  Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis.

Authors:  Surendra Dawadi; Shuhei Kawamura; Anja Rubenstein; Rory Remmel; Courtney C Aldrich
Journal:  Bioorg Med Chem       Date:  2016-02-03       Impact factor: 3.641

Review 5.  Adenylating enzymes in Mycobacterium tuberculosis as drug targets.

Authors:  Benjamin P Duckworth; Kathryn M Nelson; Courtney C Aldrich
Journal:  Curr Top Med Chem       Date:  2012       Impact factor: 3.295

6.  Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.

Authors:  Ravindranadh V Somu; Daniel J Wilson; Eric M Bennett; Helena I Boshoff; Laura Celia; Brian J Beck; Clifton E Barry; Courtney C Aldrich
Journal:  J Med Chem       Date:  2006-12-28       Impact factor: 7.446

7.  Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.

Authors:  Tony D Davis; Poornima Mohandas; Maria I Chiriac; Glennon V Bythrow; Luis E N Quadri; Derek S Tan
Journal:  Bioorg Med Chem Lett       Date:  2016-09-16       Impact factor: 2.823

8.  Investigation and conformational analysis of fluorinated nucleoside antibiotics targeting siderophore biosynthesis.

Authors:  Surendra Dawadi; Kishore Viswanathan; Helena I Boshoff; Clifton E Barry; Courtney C Aldrich
Journal:  J Org Chem       Date:  2015-04-30       Impact factor: 4.354

9.  Quantitative three dimensional structure linear interaction energy model of 5'-O-[N-(salicyl)sulfamoyl]adenosine and the aryl acid adenylating enzyme MbtA.

Authors:  Nicholas P Labello; Eric M Bennett; David M Ferguson; Courtney C Aldrich
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

10.  Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase.

Authors:  James D Patrone; Jiangwei Yao; Nicole E Scott; Garry D Dotson
Journal:  J Am Chem Soc       Date:  2009-11-18       Impact factor: 15.419
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