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Literature DB >> 16392679

FR177391, a new anti-hyperlipidemic agent from Serratia. I. Taxonomy, fermentation, isolation, physico-chemical properties, structure elucidation and biological activities.

Bunji Sato¹, Hidenori Nakajima, Takashi Fujita, Shigehiro Takase, Seiji Yoshimura, Takayoshi Kinoshita, Hiroshi Terano.

Abstract

In the course of screening for a new anti-hyperlipidemic agent from microbial products, we found that FR177391, produced by Serratia liquefaciens No. 1821, alleviated the decrease in lipid droplet formation in differentiated 3T3-L1 adipocyte cells, induced by the addition of tumor necrosis factor-alpha. Structural elucidation by spectroscopic methods and X-ray crystallographic analysis of its propylamide derivative revealed that FR177391 was a chlorinated macrocyclic lactone.

Entities: Chemical Gene Species

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Year: 2005 PMID： 16392679 DOI： 10.1038/ja.2005.87

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

6 in total

1. Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq.

Authors: Miguel A Matilla; Finian J Leeper; George P C Salmond
Journal: Environ Microbiol Date: 2015-04-08 Impact factor: 5.491

2. Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A.

Authors: Miguel A Matilla; Henning Stöckmann; Finian J Leeper; George P C Salmond
Journal: J Biol Chem Date: 2012-09-24 Impact factor: 5.157

3. Bacteriophage ϕMAM1, a viunalikevirus, is a broad-host-range, high-efficiency generalized transducer that infects environmental and clinical isolates of the enterobacterial genera Serratia and Kluyvera.

Authors: Miguel A Matilla; George P C Salmond
Journal: Appl Environ Microbiol Date: 2014-08-08 Impact factor: 4.792

FR177391, a new anti-hyperlipidemic agent from Serratia. I. Taxonomy, fermentation, isolation, physico-chemical properties, structure elucidation and biological activities.

1. Biosynthesis of the antifungal haterumalide, oocydin A, in Serratia, and its regulation by quorum sensing, RpoS and Hfq.

2. Bacterial biosynthetic gene clusters encoding the anti-cancer haterumalide class of molecules: biogenesis of the broad spectrum antifungal and anti-oomycete compound, oocydin A.

3. Bacteriophage ϕMAM1, a viunalikevirus, is a broad-host-range, high-efficiency generalized transducer that infects environmental and clinical isolates of the enterobacterial genera Serratia and Kluyvera.

4. A Plasmid-Transposon Hybrid Mutagenesis System Effective in a Broad Range of Enterobacteria.

5. Modulation of the Gut Microbiota by Krill Oil in Mice Fed a High-Sugar High-Fat Diet.

6. A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones.