Literature DB >> 16392662

Monoamine oxidase inhibitory constituents from the fruits of Cudrania tricuspidata.

Xiang Hua Han1, Seong Su Hong, Ji Sang Hwang, Seon Hwa Jeong, Ji Hye Hwang, Min Hee Lee, Myung Koo Lee, Dongho Lee, Jai Seup Ro, Bang Yeon Hwang.   

Abstract

A methylene chloride soluble fraction of the fruits of Cudrania tricuspidata significantly inhibited the mouse brain monoamine oxidase (MAO). Three known prenylated isoflavones were isolated and identified by activity-guided fractionation. Gancaonin A (1), 4'-O-methylalpinumisoflavone (2), and alpinumisoflavone (3) inhibited MAO activity in a concentration-dependent manner with IC50 values of 19.4, 23.9, and 25.8 microM, respectively. Of these, gancaonin A (1) showed a selective and potent inhibitory effect against MAO-B (IC50 0.8 microM) than MAO-A (IC50 >800 microM). The kinetic analysis using Lineweaver-Burk plots indicated that gancaonin A (1) competitively inhibited MAO-B.

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Year:  2005        PMID： 16392662     DOI： 10.1007/BF02977895

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  12 in total

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Authors:  Yang Liu; Coothan K Veena; J Brian Morgan; Kaleem A Mohammed; Mika B Jekabsons; Dale G Nagle; Yu-Dong Zhou
Journal:  J Biol Chem       Date:  2008-12-17       Impact factor: 5.157

3.  Prenylated Flavonoids from Cudrania tricuspidata Suppress Lipopolysaccharide-Induced Neuroinflammatory Activities in BV2 Microglial Cells.

Authors:  Dong-Cheol Kim; Chi-Su Yoon; Tran Hong Quang; Wonmin Ko; Jong-Su Kim; Hyuncheol Oh; Youn-Chul Kim
Journal:  Int J Mol Sci       Date:  2016-02-19       Impact factor: 5.923

4.  Comparison of pancreatic lipase inhibitory isoflavonoids from unripe and ripe fruits of Cudrania tricuspidata.

Authors:  Yang Hee Jo; Seon Beom Kim; Qing Liu; Seon-Gil Do; Bang Yeon Hwang; Mi Kyeong Lee
Journal:  PLoS One       Date:  2017-03-02       Impact factor: 3.240

5.  A Prenylated Xanthone, Cudratricusxanthone A, Isolated from Cudrania tricuspidata Inhibits Lipopolysaccharide-Induced Neuroinflammation through Inhibition of NF-κB and p38 MAPK Pathways in BV2 Microglia.

Authors:  Chi-Su Yoon; Dong-Cheol Kim; Tran Hong Quang; Jungwon Seo; Dae Gill Kang; Ho Sub Lee; Hyuncheol Oh; Youn-Chul Kim
Journal:  Molecules       Date:  2016-09-16       Impact factor: 4.411

6.  Steppogenin Isolated from Cudrania tricuspidata Shows Antineuroinflammatory Effects via NF-κB and MAPK Pathways in LPS-Stimulated BV2 and Primary Rat Microglial Cells.

Authors:  Dong-Cheol Kim; Tran Hong Quang; Hyuncheol Oh; Youn-Chul Kim
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9.  Quantitative Analysis, Extraction Optimization, and Biological Evaluation of Cudrania tricuspidata Leaf and Fruit Extracts.

Authors:  Seung-Hui Song; Sung Hwan Ki; Dae-Hun Park; Hong-Seop Moon; Chang-Dai Lee; In-Soo Yoon; Seung-Sik Cho
Journal:  Molecules       Date:  2017-09-07       Impact factor: 4.411

10.  Tyrosinase Inhibition Antioxidant Effect and Cytotoxicity Studies of the Extracts of Cudrania tricuspidata Fruit Standardized in Chlorogenic Acid.

Authors:  Ha-Na Oh; Dae-Hun Park; Ji-Yeon Park; Seung-Yub Song; Sung-Ho Lee; Goo Yoon; Hong-Seop Moon; Deuk-Sil Oh; Sang-Hoon Rhee; Eun-Ok Im; In-Soo Yoon; Jung-Hyun Shim; Seung-Sik Cho
Journal:  Molecules       Date:  2019-09-07       Impact factor: 4.411
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