Literature DB >> 16392111

Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy.

Christine M Crane1, Johannes Kaiser, Nicola L Ramsden, Susan Lauw, Felix Rohdich, Wolfgang Eisenreich, William N Hunter, Adelbert Bacher, François Diederich.   

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Year:  2006        PMID： 16392111     DOI： 10.1002/anie.200503003

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  12 in total

Review 1.  The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target.

Authors:  Hyungjin Eoh; Patrick J Brennan; Dean C Crick
Journal:  Tuberculosis (Edinb)       Date:  2008-09-14       Impact factor: 3.131

Review 2.  Biochemistry of the non-mevalonate isoprenoid pathway.

Authors:  Tobias Gräwert; Michael Groll; Felix Rohdich; Adelbert Bacher; Wolfgang Eisenreich
Journal:  Cell Mol Life Sci       Date:  2011-07-09       Impact factor: 9.261

3.  (Z)-4-Chloro-N-{3-[(4-chlorophenyl)sulfonyl]-2,3-dihydrobenzo[d]thiazol-2-ylidene}benzene-sulfonamide.

Authors:  Sydney M Watkins; Timothy J Hagen; Timothy S Perkins; Chong Zheng
Journal:  IUCrdata       Date:  2017-06-20

4.  Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.

Authors:  Carola Huthmacher; Andreas Hoppe; Sascha Bulik; Hermann-Georg Holzhütter
Journal:  BMC Syst Biol       Date:  2010-08-31

5.  2C-Methyl-d-erythritol 4-phosphate enhances and sustains cyclodiphosphate synthase IspF activity.

Authors:  J Kipchirchir Bitok; Caren Freel Meyers
Journal:  ACS Chem Biol       Date:  2012-08-06       Impact factor: 5.100

6.  Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF.

Authors:  J Kipchirchir Bitok; Caren Freel Meyers
Journal:  Medchemcomm       Date:  2013-01       Impact factor: 3.597

7.  The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery.

Authors:  Lori Buetow; Amanda C Brown; Tanya Parish; William N Hunter
Journal:  BMC Struct Biol       Date:  2007-10-23

8.  Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment.

Authors:  Patrick E F O'Rourke; Justyna Kalinowska-Tłuścik; Paul K Fyfe; Alice Dawson; William N Hunter
Journal:  BMC Struct Biol       Date:  2014-01-10

9.  Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate.

Authors:  Joy M Blain; Dakota L Grote; Sydney M Watkins; Gashaw M Goshu; Chanté Muller; James L Gorman; Gina Ranieri; Richard L Walter; Heike Hofstetter; James R Horn; Timothy J Hagen
Journal:  Bioorg Med Chem Lett       Date:  2021-07-21       Impact factor: 2.940

10.  A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy.

Authors:  Nicola L Ramsden; Lori Buetow; Alice Dawson; Lauris A Kemp; Venkatsubramanian Ulaganathan; Ruth Brenk; Gerhard Klebe; William N Hunter
Journal:  J Med Chem       Date:  2009-04-23       Impact factor: 7.446
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