Polonca Ferk1, Ksenija Gersak, Natasa Teran. 1. Department of Obstetrics and Gynaecology, Division of Medical Genetics, University Medical Centre, SI-1000 Ljubljana, Slovenia.
Abstract
PURPOSE: Women with ultrasonic evidence of polycystic ovaries are at higher risk of ovarian hyperstimulation syndrome (OHSS). We focused on investigating a possible association of the (TTTTA)(n) microsatellite polymorphism in the promoter of the CYP11A gene with OHSS during controlled ovarian hyperstimulation (COH). METHODS: We evaluated 58 patients at high risk of OHSS (study group) and 58 control patients undergoing controlled ovarian hyperstimulation. RESULTS: The difference in the allele distribution between both groups of patients was not statistically significant. The genotype distribution of 4+ (with at least one copy of the four-repeat-unit allele) and 4- (without the four-repeat-unit allele) genotypes was identical in the two groups. CONCLUSION: An association between the (TTTTA)(n) microsatellite polymorphism in the promoter of the CYP11A gene and the pathogenesis of OHSS could not be confirmed.
PURPOSE:Women with ultrasonic evidence of polycystic ovaries are at higher risk of ovarian hyperstimulation syndrome (OHSS). We focused on investigating a possible association of the (TTTTA)(n) microsatellite polymorphism in the promoter of the CYP11A gene with OHSS during controlled ovarian hyperstimulation (COH). METHODS: We evaluated 58 patients at high risk of OHSS (study group) and 58 control patients undergoing controlled ovarian hyperstimulation. RESULTS: The difference in the allele distribution between both groups of patients was not statistically significant. The genotype distribution of 4+ (with at least one copy of the four-repeat-unit allele) and 4- (without the four-repeat-unit allele) genotypes was identical in the two groups. CONCLUSION: An association between the (TTTTA)(n) microsatellite polymorphism in the promoter of the CYP11A gene and the pathogenesis of OHSS could not be confirmed.
Authors: N Gharani; D M Waterworth; S Batty; D White; C Gilling-Smith; G S Conway; M McCarthy; S Franks; R Williamson Journal: Hum Mol Genet Date: 1997-03 Impact factor: 6.150
Authors: M Urbanek; R S Legro; D A Driscoll; R Azziz; D A Ehrmann; R J Norman; J F Strauss; R S Spielman; A Dunaif Journal: Proc Natl Acad Sci U S A Date: 1999-07-20 Impact factor: 11.205