| Literature DB >> 1639175 |
S Guarini1, C Bazzani, S Tagliavini, A Bertolini, W Ferrari.
Abstract
In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition--without the need for reinfusion of the shed blood--starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.Entities:
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Year: 1992 PMID： 1639175 DOI： 10.1007/bf02118314
Source DB: PubMed Journal: Experientia ISSN： 0014-4754