Literature DB >> 16391476

Neuropathologic correlates of apathy in Alzheimer's disease.

Gad A Marshall1, Lynn A Fairbanks, Sibel Tekin, Harry V Vinters, Jeffrey L Cummings.   

Abstract

Apathy is the most commonly observed behavioral disturbance in Alzheimer's disease (AD) and has been suggested to be frontally mediated. Neuritic plaque (NP) and neurofibrillary tangle (NFT) counts were performed for 8 brain regions in 29 subjects with definite AD. Neuropsychiatric Inventory (NPI) for autopsied subjects was obtained from questioning of caregivers of subjects included in the study. Chronic apathy and total NPI composite scores correlated with anterior cingulate NFT counts (r = 0.518, p = 0.01, and r = 0.438, p = 0.032). This analysis suggests that chronic apathy in AD correlates with a greater anterior cingulate NFT burden and that chronic behavioral changes are more reflective than acute changes of disease pathology.

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Year:  2006        PMID： 16391476     DOI： 10.1159/000090674

Source DB:  PubMed          Journal:  Dement Geriatr Cogn Disord        ISSN： 1420-8008            Impact factor:   2.959


  32 in total

Review 1.  Apathy in neuropsychiatric disease: diagnosis, pathophysiology, and treatment.

Authors:  Thomas N Chase
Journal:  Neurotox Res       Date:  2010-05-15       Impact factor: 3.911

2.  Functional correlates of instrumental activities of daily living in mild Alzheimer's disease.

Authors:  Neelesh K Nadkarni; Naama Levy-Cooperman; Sandra E Black
Journal:  Neurobiol Aging       Date:  2010-03-31       Impact factor: 4.673

3.  Brain microstructure of subclinical apathy phenomenology in healthy individuals.

Authors:  Gianfranco Spalletta; Sabrina Fagioli; Carlo Caltagirone; Fabrizio Piras
Journal:  Hum Brain Mapp       Date:  2012-07-17       Impact factor: 5.038

4.  Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network.

Authors:  John M Ringman; Li-Jung Liang; Yan Zhou; Sitaram Vangala; Edmond Teng; Sarah Kremen; David Wharton; Alison Goate; Daniel S Marcus; Martin Farlow; Bernardino Ghetti; Eric McDade; Colin L Masters; Richard P Mayeux; Martin Rossor; Stephen Salloway; Peter R Schofield; Jeffrey L Cummings; Virginia Buckles; Randall Bateman; John C Morris
Journal:  Brain       Date:  2015-02-15       Impact factor: 13.501

5.  Neural correlates of apathy in late-life depression: a pilot [18 F]FDDNP positron emission tomography study.

Authors:  Harris A Eyre; Prabha Siddarth; Kathleen van Dyk; Natalie St Cyr; Bernhard T Baune; Jorge R Barrio; Gary W Small; Helen Lavretsky
Journal:  Psychogeriatrics       Date:  2017-01-28       Impact factor: 2.440

6.  Insight in Alzheimer's disease and its relation to psychiatric and behavioral disturbances.

Authors:  Sheena M Horning; Rebecca Melrose; David Sultzer
Journal:  Int J Geriatr Psychiatry       Date:  2013-05-14       Impact factor: 3.485

7.  Neural correlates of apathy revealed by lesion mapping in participants with traumatic brain injuries.

Authors:  Kristine M Knutson; Olga Dal Monte; Vanessa Raymont; Eric M Wassermann; Frank Krueger; Jordan Grafman
Journal:  Hum Brain Mapp       Date:  2013-02-13       Impact factor: 5.038

8.  Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum.

Authors:  Lauren P Wadsworth; Natacha Lorius; Nancy J Donovan; Joseph J Locascio; Dorene M Rentz; Keith A Johnson; Reisa A Sperling; Gad A Marshall
Journal:  Dement Geriatr Cogn Disord       Date:  2012-08-28       Impact factor: 2.959

9.  Neuroanatomical correlates of apathy in late-life depression and antidepressant treatment response.

Authors:  Genevieve S Yuen; Faith M Gunning; Eric Woods; Sibel A Klimstra; Matthew J Hoptman; George S Alexopoulos
Journal:  J Affect Disord       Date:  2014-05-22       Impact factor: 4.839

10.  Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia.

Authors:  Gad A Marshall; Jennifer R Gatchel; Nancy J Donovan; Martha C Muniz; Aaron P Schultz; J Alex Becker; Jasmeer P Chhatwal; Bernard J Hanseeuw; Kathryn V Papp; Rebecca E Amariglio; Dorene M Rentz; Reisa A Sperling; Keith A Johnson
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472
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