OBJECTIVE: A double-blind randomized controlled-trial was done to evaluate the efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea. METHODS:All children from 6 months to 12 years with acute diarrhea were included. Lactobacillus acidophilus/placebo was given to the children for 3 days with ORS and feeds. Intake-output was recorded 4 hourly. Of the 98 children, 48 received lactobacillus and 50 theplacebo. RESULTS:ORS consumed, frequency of stools, duration of diarrhea, time for rehydration, hospital stay, weight gain and IVF needed were comparable in the two study groups. There were 4 treatment failures in the lactobacillus group and none in the placebo group (OR 0.92, 95%CI 0.84-0.99). In the rotaviral diarrhea and in those who had diarrhea of less then 60 hours the difference did not reach statistical significance. CONCLUSION: There is no significant benefit of tyndalized Lactobacillus acidophilus in acute diarrhea.
RCT Entities:
OBJECTIVE: A double-blind randomized controlled-trial was done to evaluate the efficacy of tyndalized Lactobacillus acidophilus in acute diarrhea. METHODS: All children from 6 months to 12 years with acute diarrhea were included. Lactobacillus acidophilus/placebo was given to the children for 3 days with ORS and feeds. Intake-output was recorded 4 hourly. Of the 98 children, 48 received lactobacillus and 50 the placebo. RESULTS: ORS consumed, frequency of stools, duration of diarrhea, time for rehydration, hospital stay, weight gain and IVF needed were comparable in the two study groups. There were 4 treatment failures in the lactobacillus group and none in the placebo group (OR 0.92, 95%CI 0.84-0.99). In the rotaviral diarrhea and in those who had diarrhea of less then 60 hours the difference did not reach statistical significance. CONCLUSION: There is no significant benefit of tyndalized Lactobacillus acidophilus in acute diarrhea.
Authors: S Guandalini; L Pensabene; M A Zikri; J A Dias; L G Casali; H Hoekstra; S Kolacek; K Massar; D Micetic-Turk; A Papadopoulou; J S de Sousa; B Sandhu; H Szajewska; Z Weizman Journal: J Pediatr Gastroenterol Nutr Date: 2000-01 Impact factor: 2.839
Authors: N Simakachorn; V Pichaipat; P Rithipornpaisarn; C Kongkaew; P Tongpradit; W Varavithya Journal: J Pediatr Gastroenterol Nutr Date: 2000-01 Impact factor: 2.839
Authors: Hugo Costa-Ribeiro; Tereza Cristina M Ribeiro; Angela P Mattos; Sandra S Valois; Daniela A Neri; Patricia Almeida; Celina M Cerqueira; Eduardo Ramos; Rosemary J Young; Jon A Vanderhoof Journal: J Pediatr Gastroenterol Nutr Date: 2003-01 Impact factor: 2.839
Authors: Geoffrey A Preidis; Colin Hill; Richard L Guerrant; B S Ramakrishna; Gerald W Tannock; James Versalovic Journal: Gastroenterology Date: 2010-11-12 Impact factor: 22.682
Authors: Shelui Collinson; Andrew Deans; April Padua-Zamora; Germana V Gregorio; Chao Li; Leonila F Dans; Stephen J Allen Journal: Cochrane Database Syst Rev Date: 2020-12-08