OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is thought to play a role in immune activation in preeclampsia. The objective of this study was to establish if soluble TNF-receptor I (sTNF-rI) levels relate to the onset and severity of preeclampsia. METHODS: Maternal plasma sTNF-rI levels were studied throughout pregnancy in 68 women with a history of severe preeclampsia or intra-uterine growth restriction (IUGR), and primigravidas with chronic hypertension. Data are presented as mean (SD) in ng/ml. RESULTS: In the second trimester there was a significant difference in sTNF-rI levels between preeclamptic pregnancies with and without IUGR (means 1.33 (0.20) and 1.11 (0.15) respectively, p < 0.005). In severe preeclampsia with delivery before 34 weeks of gestation, sTNF-rI levels were higher than in mild preeclampsia in the second and third trimesters (means 1.40 (0.16) vs. 1.16 (0.19), p < 0.02 and 1.82 (0.47) vs. 1.42 (0.22), p < 0.05, respectively). CONCLUSION: sTNF-rI levels were higher in preeclampsia with fetal involvement, suggesting that increased TNF-alpha production in preeclampsia is related to impaired placentation rather than to the maternal syndrome.
OBJECTIVE:Tumor necrosis factor-alpha (TNF-alpha) is thought to play a role in immune activation in preeclampsia. The objective of this study was to establish if soluble TNF-receptor I (sTNF-rI) levels relate to the onset and severity of preeclampsia. METHODS: Maternal plasma sTNF-rI levels were studied throughout pregnancy in 68 women with a history of severe preeclampsia or intra-uterine growth restriction (IUGR), and primigravidas with chronic hypertension. Data are presented as mean (SD) in ng/ml. RESULTS: In the second trimester there was a significant difference in sTNF-rI levels between preeclamptic pregnancies with and without IUGR (means 1.33 (0.20) and 1.11 (0.15) respectively, p < 0.005). In severe preeclampsia with delivery before 34 weeks of gestation, sTNF-rI levels were higher than in mild preeclampsia in the second and third trimesters (means 1.40 (0.16) vs. 1.16 (0.19), p < 0.02 and 1.82 (0.47) vs. 1.42 (0.22), p < 0.05, respectively). CONCLUSION: sTNF-rI levels were higher in preeclampsia with fetal involvement, suggesting that increased TNF-alpha production in preeclampsia is related to impaired placentation rather than to the maternal syndrome.
Authors: Sandra A Founds; Robert W Powers; Thelma E Patrick; Dianxu Ren; Gail F Harger; Nina Markovic; James M Roberts Journal: Hypertens Pregnancy Date: 2008 Impact factor: 2.108
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Authors: Babbette D LaMarca; Derrick L Chandler; Lee Grubbs; Jennifer Bain; Gerald R McLemore; Joey P Granger; Michael J Ryan Journal: Am J Hypertens Date: 2007-11 Impact factor: 2.689
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Authors: Baha Sibai; Roberto Romero; Mark A Klebanoff; Madeline Murguia Rice; Steve Caritis; Marshall D Lindheimer; J Peter Van Dorsten; Mark Landon; Menachem Miodovnik; Mitchell Dombrowski; Paul Meis Journal: Am J Obstet Gynecol Date: 2009-06 Impact factor: 8.661