OBJECTIVE: Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI). METHOD: Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7-14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume. RESULTS: Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects. CONCLUSION: Our findings provide new evidence of abnormal thalamic volume in pediatric TS.
OBJECTIVE: Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI). METHOD: Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7-14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume. RESULTS:Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects. CONCLUSION: Our findings provide new evidence of abnormal thalamic volume in pediatric TS.
Authors: Ann M Miller; Ravi Bansal; Xuejun Hao; Juan Pablo Sanchez-Pena; Loren J Sobel; Jun Liu; Dongrong Xu; Hongtu Zhu; M Mallar Chakravarty; Kathleen Durkin; Iliyan Ivanov; Kerstin J Plessen; Christoph B Kellendonk; Bradley S Peterson Journal: Arch Gen Psychiatry Date: 2010-09
Authors: Alicja Lerner; Anto Bagic; Janine M Simmons; Zoltan Mari; Omer Bonne; Ben Xu; Diane Kazuba; Peter Herscovitch; Richard E Carson; Dennis L Murphy; Wayne C Drevets; Mark Hallett Journal: Brain Date: 2012-05-10 Impact factor: 13.501
Authors: Tulio Guadalupe; Samuel R Mathias; Theo G M vanErp; Christopher D Whelan; Marcel P Zwiers; Yoshinari Abe; Lucija Abramovic; Ingrid Agartz; Ole A Andreassen; Alejandro Arias-Vásquez; Benjamin S Aribisala; Nicola J Armstrong; Volker Arolt; Eric Artiges; Rosa Ayesa-Arriola; Vatche G Baboyan; Tobias Banaschewski; Gareth Barker; Mark E Bastin; Bernhard T Baune; John Blangero; Arun L W Bokde; Premika S W Boedhoe; Anushree Bose; Silvia Brem; Henry Brodaty; Uli Bromberg; Samantha Brooks; Christian Büchel; Jan Buitelaar; Vince D Calhoun; Dara M Cannon; Anna Cattrell; Yuqi Cheng; Patricia J Conrod; Annette Conzelmann; Aiden Corvin; Benedicto Crespo-Facorro; Fabrice Crivello; Udo Dannlowski; Greig I de Zubicaray; Sonja M C de Zwarte; Ian J Deary; Sylvane Desrivières; Nhat Trung Doan; Gary Donohoe; Erlend S Dørum; Stefan Ehrlich; Thomas Espeseth; Guillén Fernández; Herta Flor; Jean-Paul Fouche; Vincent Frouin; Masaki Fukunaga; Jürgen Gallinat; Hugh Garavan; Michael Gill; Andrea Gonzalez Suarez; Penny Gowland; Hans J Grabe; Dominik Grotegerd; Oliver Gruber; Saskia Hagenaars; Ryota Hashimoto; Tobias U Hauser; Andreas Heinz; Derrek P Hibar; Pieter J Hoekstra; Martine Hoogman; Fleur M Howells; Hao Hu; Hilleke E Hulshoff Pol; Chaim Huyser; Bernd Ittermann; Neda Jahanshad; Erik G Jönsson; Sarah Jurk; Rene S Kahn; Sinead Kelly; Bernd Kraemer; Harald Kugel; Jun Soo Kwon; Herve Lemaitre; Klaus-Peter Lesch; Christine Lochner; Michelle Luciano; Andre F Marquand; Nicholas G Martin; Ignacio Martínez-Zalacaín; Jean-Luc Martinot; David Mataix-Cols; Karen Mather; Colm McDonald; Katie L McMahon; Sarah E Medland; José M Menchón; Derek W Morris; Omar Mothersill; Susana Munoz Maniega; Benson Mwangi; Takashi Nakamae; Tomohiro Nakao; Janardhanan C Narayanaswaamy; Frauke Nees; Jan E Nordvik; A Marten H Onnink; Nils Opel; Roel Ophoff; Marie-Laure Paillère Martinot; Dimitri Papadopoulos Orfanos; Paul Pauli; Tomáš Paus; Luise Poustka; Janardhan Yc Reddy; Miguel E Renteria; Roberto Roiz-Santiáñez; Annerine Roos; Natalie A Royle; Perminder Sachdev; Pascual Sánchez-Juan; Lianne Schmaal; Gunter Schumann; Elena Shumskaya; Michael N Smolka; Jair C Soares; Carles Soriano-Mas; Dan J Stein; Lachlan T Strike; Roberto Toro; Jessica A Turner; Nathalie Tzourio-Mazoyer; Anne Uhlmann; Maria Valdés Hernández; Odile A van den Heuvel; Dennis van der Meer; Neeltje E M van Haren; Dick J Veltman; Ganesan Venkatasubramanian; Nora C Vetter; Daniella Vuletic; Susanne Walitza; Henrik Walter; Esther Walton; Zhen Wang; Joanna Wardlaw; Wei Wen; Lars T Westlye; Robert Whelan; Katharina Wittfeld; Thomas Wolfers; Margaret J Wright; Jian Xu; Xiufeng Xu; Je-Yeon Yun; JingJing Zhao; Barbara Franke; Paul M Thompson; David C Glahn; Bernard Mazoyer; Simon E Fisher; Clyde Francks Journal: Brain Imaging Behav Date: 2017-10 Impact factor: 3.978
Authors: Soyoung Kim; Deanna J Greene; Carolina Badke D'Andrea; Emily C Bihun; Jonathan M Koller; Bridget O'Reilly; Bradley L Schlaggar; Kevin J Black Journal: J Clin Med Date: 2020-06-03 Impact factor: 4.241