AIMS: Stress hormones might be involved in motion sickness. The influence of loperamide on kinetosis-induced nausea and stress hormone release was investigated in a placebo-controlled, cross-over study. METHODS:Standardized rotation around the vertical axis combined with head movements was used to induce nausea 3 h after 16 mg loperamide or placebo (n = 8). Plasma antidiuretic hormone (ADH), adrenocorticotropic hormone (ACTH) and nausea ratings were investigated. RESULTS: After loperamide nausea was significantly lower (P < 0.02). ACTH (P < 0.05) and ADH levels (P < 0.02) increased significantly in both settings, but were lower after loperamide. CONCLUSIONS: The susceptibility to develop kinetosis-induced nausea and stress hormone release is decreased by loperamide, although the site of action remains speculative.
RCT Entities:
AIMS: Stress hormones might be involved in motion sickness. The influence of loperamide on kinetosis-induced nausea and stress hormone release was investigated in a placebo-controlled, cross-over study. METHODS: Standardized rotation around the vertical axis combined with head movements was used to induce nausea 3 h after 16 mg loperamide or placebo (n = 8). Plasma antidiuretic hormone (ADH), adrenocorticotropic hormone (ACTH) and nausea ratings were investigated. RESULTS: After loperamidenausea was significantly lower (P < 0.02). ACTH (P < 0.05) and ADH levels (P < 0.02) increased significantly in both settings, but were lower after loperamide. CONCLUSIONS: The susceptibility to develop kinetosis-induced nausea and stress hormone release is decreased by loperamide, although the site of action remains speculative.
Authors: S Klosterhalfen; A Rüttgers; E Krumrey; B Otto; U Stockhorst; R L Riepl; T Probst; P Enck Journal: Psychosom Med Date: 2000 Sep-Oct Impact factor: 4.312
Authors: R L Riepl; B Reichardt; C J Auernhammer; G Beier; J Schopohl; G K Stalla; P Lehnert Journal: Br J Clin Pharmacol Date: 1996-09 Impact factor: 4.335
Authors: Nicolas Rohleder; Bärbel Otto; Jutta M Wolf; Joachim Klose; Clemens Kirschbaum; Paul Enck; Sibylle Klosterhalfen Journal: Psychoneuroendocrinology Date: 2005-09-06 Impact factor: 4.905